Cowden disease

MONDO:0016063

A genodermatosis characterized by the presence of multiple hamartomas in various tissues and an increased risk for malignancies of the breast, thyroid, endometrium, kidney and colorectum. When CS is accompanied by germline PTEN mutations, it belongs to the PTEN hamartoma tumor syndrome (PHTS) group.

Also known as: Cowden disease, Cowden syndrome, Cowden's disease, multiple hamartoma syndrome, CD, MHAM, dysplastic gangliocytoma of cerebellum

11 clinical trials for this condition and its sub-types, 11 tagged with Cowden disease itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary skin disorder (885) ↑ Autosomal dominant disease (699)

Sub-types of Cowden disease

Cowden syndrome 1 1 trial
Cowden syndrome 2 0 trials
Cowden syndrome 3 0 trials
Cowden syndrome 4 0 trials
Cowden syndrome 5 0 trials
Cowden syndrome 6 0 trials
Cowden syndrome 7 0 trials
Sacral hemangiomas multiple congenital abnormalities 0 trials

Including sub-types (11) Tagged with Cowden disease (11)

Trials to join now! 5 Not yet recruiting 1 Not yet finished but already full! 3 Completed 2

Could a cancer drug boost social abilities in rare genetic condition?

Disease control Not yet recruiting

This study tests whether everolimus, a drug already approved for other conditions, can safely improve social abilities in people with PTEN Hamartoma Tumor Syndrome (PHTS). About 60 adults and children with PHTS and social difficulties will take either everolimus or a placebo for …

Phase 2/3 • Sponsor: Boston Children's Hospital • Aim: Disease control

Last updated Jun 27, 2026 13:03 UTC

Cowden disease

Where it sits in the disease tree

Could a cancer drug boost social abilities in rare genetic condition?