Collagenous sprue

A rare disorder affecting the digestive tract. Its cause is unclear but may be attributed, in part, to increased collagen synthesis without adequate fibrolysis. It is characterized histologically by atrophy of mucosal villi and crypts with extensive subepithelial collagen deposition. Clinical signs include nausea, vomiting, diarrhea and weight loss. Unlike celiac sprue (celiac disease), a gluten-free diet does not predict a certain regression of the disease. The clinical course follows a progression of malabsorption leading to nutritional deficiencies, small bowel ulceration/perforation, lymphoma and infection. Prognosis is usually dismal.

Also known as: collagenous sprue, non-gluten sensitive enteropathy syndrome, Sprues, collagenous, collagenous Sprues, collagenous enteropathy, collagenous enteropathy syndrome, non-gluten intolerance syndrome, sprue, collagenous

1 clinical trial for this condition and its sub-types, 0 tagged with Collagenous sprue itself.