Cogan syndrome

MONDO:0015453

Cogan syndrome (CS) is a rare autoimmune disorder of unknown origin characterized by inflammatory ocular disease (mainly interstitial keratitis) and vestibulo-auditory manifestations (mainly acute onset hearing loss, tinnitus and vertigo), in the setting of a negative work-up for syphilis, with a variable risk of developing into a systemic disease. Systemic manifestations may occur in more than 70% of cases.

Also known as: Cogan syndrome

33 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Autoimmune disease (305) Immune system disorder (148) Eye disorder (102) Human disease (14) Otorhinolaryngologic disease (14) Disorder of orbital region (3) Disorder of visual system (1) Autoimmune disease of ear, nose and throat (0) Disease by body system or component (0)

Trials to join now! 13 Not yet recruiting 5 Not yet finished but already full! 6 Completed 8 Terminated 1

Biopsy tolerance study ends early – what we know

Knowledge-focused Terminated

This study aimed to understand how well patients tolerate biopsies for autoimmune diseases and whether they feel properly informed. It planned to enroll 505 people but was terminated early. The results may help improve patient experience with these common procedures.

Sponsor: University Hospital, Brest • Aim: Knowledge-focused

Last updated Jun 28, 2026 00:00 UTC

Cogan syndrome

Broader categories

Biopsy tolerance study ends early – what we know