Cluster headache syndrome
MONDO:0043537A headache disorder that is characterized by periodic severe, unilateral orbital, supraorbital, and/or temporal pain, and is associated with ipsilateral cranial autonomic symptoms.
Also known as: Cephalgia, histamine, Cephalgias, histamine, Horton headache, Horton syndrome, Horton's headache, Horton's neuralgia, Horton's syndrome, Hortons syndrome
32 clinical trials for this condition and its sub-types, 26 tagged with Cluster headache syndrome itself.
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Browse by category →Sub-types of Cluster headache syndrome
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Cluster headache, familial 0 trials
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New hope for nighttime cluster headaches: Low-Sodium drug enters trial
Symptom relief Not yet recruitingThis phase 2 trial tests whether low sodium oxybate (Xywav) can reduce nighttime cluster headache attacks in people with chronic cluster headache. About 52 participants will receive either the drug or a placebo for 16 weeks. The main goal is to see if the drug lowers the number o…
Phase 2 • Sponsor: Leiden University Medical Center • Aim: Symptom relief
Last updated Aug 27, 2026 00:00 UTC
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Nasal spray could offer rapid relief for debilitating cluster headaches
Symptom relief Not yet recruitingThis pilot study tests whether zavegepant nasal spray can quickly relieve pain from episodic cluster headaches. About 40 adults with episodic cluster headaches will use the spray at the start of an attack. The main goal is to see how many achieve minimal or no pain within 30 minu…
Phase 2 • Sponsor: The University of Texas Health Science Center, Houston • Aim: Symptom relief
Last updated Jul 22, 2026 00:00 UTC