Classic familial adenomatous polyposis
MONDO:0021055Familial adenomatous polyposis (FAP) is characterized by the development of hundreds to thousands of adenomas in the rectum and colon during the second decade of life.
Also known as: FAP, Familial Adenomatous Polyposis, adenomatous polyposis coli, classic FAP, classic familial adenomatous polyposis, colorectal adenomatous polyposis, familial adenomatous polyposis, familial adenomatous polyposis coli
64 clinical trials for this condition and its sub-types.
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Broader categories
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Could a liver drug tame polyps in rare gut condition?
Disease control TerminatedThis study tested whether obeticholic acid, a drug already used for liver disease, can safely reduce the number of polyps in the small bowel and colon in people with familial adenomatous polyposis (FAP). FAP is a rare genetic condition that greatly raises the risk of intestinal c…
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Study checks if stopping a drug made polyps grow faster
Knowledge-focused TerminatedThis study reviewed medical records of 42 people with familial adenomatous polyposis (FAP) who had previously taken the drug erlotinib. Researchers wanted to see how quickly the disease progressed after the drug was stopped. The goal was to better understand what happens when tre…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC