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Chronic recurrent multifocal osteomyelitis

MONDO:0009813

Chronic non bacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a chronic autoinflammatory syndrome that is characterized by multiple foci of painful swelling of bones, mainly in the metaphyses of the long bones, in addition to the pelvis, the shoulder girdle and the spine.

Also known as: CNO/CRMO, CRMO, NBO, chronic multifocal osteomyelitis, chronic recurrent multifocal osteomyelitis, chronic recurrent multifocal osteomyelitis (disease), non-bacterial osteomyelitis, CMO

20 clinical trials for this condition and its sub-types, 3 tagged with Chronic recurrent multifocal osteomyelitis itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary disorder of connective tissue (1314) ↑ Autoinflammatory syndrome (208) ↑ Osteomyelitis (46)

Sub-types of Chronic recurrent multifocal osteomyelitis

Sterile multifocal osteomyelitis with periostitis and pustulosis 2 trials
Majeed syndrome 0 trials
Chronic recurrent multifocal osteomyelitis 3 0 trials

Including sub-types (20) Tagged with Chronic recurrent multifocal osteomyelitis (3)

Trials to join now! 1 Not yet recruiting 1 Completed 1

NIH launches major study to unlock secrets of rare inflammatory diseases

Knowledge-focused Completed

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) • Aim: Knowledge-focused

Last updated Sep 18, 2026 00:00 UTC

Chronic recurrent multifocal osteomyelitis

Where it sits in the disease tree

NIH launches major study to unlock secrets of rare inflammatory diseases