Chronic primary adrenal insufficiency

MONDO:0015129

A chronic disorder of the adrenal cortex resulting in the inadequate production of glucocorticoid and mineralocorticoid hormones.

Also known as: CPAI, chronic adrenocorticoid insufficiency, hypoadrenocorticism, familial, primary adrenal insufficiency, chronic, primary hypoadrenalism, Addison disease, chronic adrenal insufficiency, adrenal aplasia, adrenal gland hypofunction

49 clinical trials for this condition and its sub-types, 6 tagged with Chronic primary adrenal insufficiency itself.

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Where it sits in the disease tree

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↑ Primary adrenal insufficiency (48)

Sub-types of Chronic primary adrenal insufficiency

Congenital adrenal hyperplasia 36 trials · 38 incl. sub-types
8 sub-types
Triple-A syndrome 3 trials
X-linked adrenal hypoplasia congenita 0 trials
1 sub-type
- Adrenal hypoplasia, cytomegalic type 0 trials
Adrenocortical hypofunction, chronic primary congenital 0 trials
Autoimmune primary adrenal insufficiency 0 trials
Familial adrenal hypoplasia with absent pituitary luteinizing hormone 0 trials
Familial glucocorticoid deficiency 0 trials
6 sub-types
- Adrenocortical unresponsiveness to ACTH with postreceptor defect 0 trials
- Glucocorticoid deficiency 1 0 trials
- Glucocorticoid deficiency 2 0 trials
- Glucocorticoid deficiency 3 0 trials
- Glucocorticoid deficiency 4 0 trials
- Glucocorticoid deficiency 5 0 trials
Inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency 0 trials

Most studied deeper sub-types

Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, salt wasting form (0) Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form (0) Classic congenital lipoid adrenal hyperplasia due to STAR deficency (0) Non-classic congenital lipoid adrenal hyperplasia due to STAR deficency (0)

Including sub-types (49) Tagged with Chronic primary adrenal insufficiency (6)

Trials to join now! 3 Not yet recruiting 1 Not yet finished but already full! 1 Completed 1

Two hydrocortisone pills go Head-to-Head in adrenal insufficiency trial

Disease control Completed

Researchers are comparing two modified-release hydrocortisone pills, Chronocort and Plenadren, in adults with primary adrenal insufficiency, a condition where the adrenal glands do not make enough cortisol. The study is a phase 2, double-blind, crossover trial: participants recei…

Phase 2 • Sponsor: Neurocrine UK Limited • Aim: Disease control

Last updated Sep 16, 2026 00:00 UTC

Chronic primary adrenal insufficiency

Where it sits in the disease tree

Most studied deeper sub-types

Two hydrocortisone pills go Head-to-Head in adrenal insufficiency trial