Choriocarcinoma
MONDO:0005207An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected.
Also known as: chorioblastoma, choriocarcinoma, choriocarcinoma (disease), choriocarcinoma, malignant, chorioepithelioma, chorion carcinoma, chorionic carcinoma
1434 clinical trials for this condition and its sub-types, 4 tagged with Choriocarcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Choriocarcinoma
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Choriocarcinoma of ovary 1 trial
2 sub-types
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Choriocarcinoma of testis 1 trial
2 sub-types
- Childhood testicular choriocarcinoma 0 trials
- Testicular monophasic choriocarcinoma 0 trials
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Gestational choriocarcinoma 0 trials · 1 incl. sub-types
4 sub-types
- Placental choriocarcinoma 1 trial
- Fallopian tube gestational choriocarcinoma 0 trials
- Gestational ovarian choriocarcinoma 0 trials
- Uterine corpus choriocarcinoma 0 trials
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3 sub-types
- Adult central nervous system choriocarcinoma 0 trials
- Pediatric CNS choriocarcinoma 0 trials
- Pineal region choriocarcinoma 0 trials
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Gastric choriocarcinoma 0 trials
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Non-gestational choriocarcinoma 0 trials
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Placental site trophoblastic tumor 0 trials
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Pulmonary artery choriocarcinoma 0 trials
Most studied deeper sub-types
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Tailored treatment may reduce radiation side effects in young brain tumor patients
Disease control Recruiting nowThis phase 2 trial tests a personalized approach for children and young adults with a rare brain tumor called non-germinomatous germ cell tumor (NGGCT). Patients first receive chemotherapy, and then the type and amount of radiation they get depends on how well the tumor responds.…
Phase 2 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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Major trial tests gentler chemo for germ cell tumors
Disease control Recruiting nowThis phase 3 trial studies two approaches for germ cell tumors. For low-risk patients whose tumor has been removed, doctors will monitor them closely instead of giving chemotherapy. For standard-risk patients whose cancer has spread, the trial compares two chemotherapy drugs—carb…
Phase 3 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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Massive study tracks 1,100+ kids after cancer treatment to uncover hidden risks
Knowledge-focused Recruiting nowThis study follows over 1,100 children who were treated for germ cell tumors (a type of cancer). Researchers want to learn about long-term side effects like hearing loss and to analyze tumor DNA to better predict which children might have their cancer come back. Participants prov…
Sponsor: Children's Oncology Group • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC