Cherubism

MONDO:0007315

Cherubism is a rare, self-limiting, fibro-osseous, genetic disease of childhood and adolescence characterized by varying degrees of progressive bilateral enlargement of the mandible and/or maxilla, with clinical repercussions in severe cases.

Also known as: CRBM, cherubism, familial fibrous dysplasia of the jaws, familial multilocular cystic disease of the jaws, Crbm

43 clinical trials for this condition and its sub-types, 1 tagged with Cherubism itself.

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Where it sits in the disease tree

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Part of

↑ Skeletal system disorder (9715) ↑ Hereditary disorder of connective tissue (1311) ↑ Hereditary neoplastic syndrome (731) ↑ Autosomal dominant disease (699) ↑ Autoinflammatory syndrome (207) ↑ Multiple congenital anomalies/dysmorphic syndrome without intellectual disability (163)

Sub-types of Cherubism

Al Gazali Khidr Prem Chandran syndrome 0 trials

Including sub-types (43) Tagged with Cherubism (1)

Trials to join now! 1

Scientists hunt for cherubism genes in 600-Person study

Knowledge-focused Recruiting now

This study aims to find the genes and DNA changes that cause cherubism, a rare condition that affects the jaw bones. Researchers will study blood and tissue samples from up to 600 people, including patients and their family members. The long-term goal is to understand the disease…

Sponsor: UConn Health • Aim: Knowledge-focused

Last updated Jun 27, 2026 12:08 UTC

Cherubism

Where it sits in the disease tree

Scientists hunt for cherubism genes in 600-Person study