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CHEK2-related cancer predisposition

MONDO:0700271

Hereditary cancer predisposition due to variation(s) in the CHEK2 gene. Pathogenic germline variation in CHEK2 confers an autosomal dominant predisposition to tumor formation at multiple primary sites, including breast cancer and prostate cancer.

39 clinical trials for this condition and its sub-types, 7 tagged with CHEK2-related cancer predisposition itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary neoplastic syndrome (731)

Including sub-types (39) Tagged with CHEK2-related cancer predisposition (7)

Trials to join now! 2 Not yet recruiting 1 Not yet finished but already full! 2 Completed 1 Terminated 1

Could a 'Baby Dose' of hormone pills prevent breast cancer?

Prevention Not yet recruiting

This study tests whether low doses of two hormone-blocking drugs, exemestane and tamoxifen, can help prevent breast cancer in postmenopausal women at high risk. About 140 women will take one of the two drugs for a year, and researchers will measure side effects and quality of lif…

Phase 2 • Sponsor: Dana-Farber Cancer Institute • Aim: Prevention

Last updated Jun 27, 2026 12:01 UTC