Central nervous system neoplasm
MONDO:0006130A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia.
Also known as: CNS neoplasm, CNS tumor, CNS tumour, brain/spinal cord tumor, brain/spinal cord tumour, central nervous system neoplasm, central nervous system neoplasm (disease), central nervous system tumor
3348 clinical trials for this condition and its sub-types, 51 tagged with Central nervous system neoplasm itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Central nervous system neoplasm
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Central nervous system cancer 130 trials · 1,699 incl. sub-types
20 sub-types
- Malignant glioma 250 trials · 915 incl. sub-types Sub-types →
- Brain cancer 680 trials · 900 incl. sub-types Sub-types →
- Primary central nervous system lymphoma 92 trials · 103 incl. sub-types Sub-types →
- Central nervous system sarcoma 2 trials · 74 incl. sub-types Sub-types →
- Spinal cord cancer 21 trials · 57 incl. sub-types Sub-types →
- Central nervous system primitive neuroectodermal neoplasm 8 trials · 24 incl. sub-types Sub-types →
- Central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor 1 trial · 22 incl. sub-types Sub-types →
- Malignant tumor of meninges 0 trials · 14 incl. sub-types Sub-types →
- Malignant adrenal gland pheochromocytoma 11 trials
- Central nervous system germinoma 2 trials · 4 incl. sub-types Sub-types →
- Central nervous system melanocytic neoplasm 1 trial · 4 incl. sub-types Sub-types →
- Central nervous system endodermal sinus tumor 0 trials · 1 incl. sub-types Sub-types →
- Choriocarcinoma of the central nervous system 0 trials Sub-types →
- Embryonal carcinoma of the central nervous system 0 trials Sub-types →
- Malignant carotid body paraganglioma 0 trials
- Malignant central nervous system mesenchymal, non-meningothelial neoplasm 0 trials Sub-types →
- Malignant jugulotympanic paraganglioma 0 trials
- Mixed germ cell tumor of central nervous system 0 trials Sub-types →
- Pheochromocytoma/paraganglioma syndrome 2 0 trials
- Pheochromocytoma/paraganglioma syndrome 5 0 trials
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Brain neoplasm 246 trials · 1,077 incl. sub-types
17 sub-types
- Brain cancer 680 trials · 900 incl. sub-types Sub-types →
- Cerebellar neoplasm 3 trials · 114 incl. sub-types Sub-types →
- Infratentorial neoplasm 6 trials · 114 incl. sub-types Sub-types →
- Brainstem neoplasm 0 trials · 101 incl. sub-types Sub-types →
- Primary brain neoplasm 87 trials · 92 incl. sub-types Sub-types →
- Hypothalamic neoplasm 3 trials · 85 incl. sub-types Sub-types →
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
- Benign neoplasm of brain 16 trials · 21 incl. sub-types Sub-types →
- Choroid plexus neoplasm 5 trials · 18 incl. sub-types Sub-types →
- Neoplasm of cerebral hemisphere 3 trials · 14 incl. sub-types Sub-types →
- Optic pathway glioma 11 trials Sub-types →
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Cerebellopontine angle tumor 1 trial Sub-types →
- Dysembryoplastic neuroepithelial tumor 1 trial
- Childhood brain meningioma 0 trials
- Olfactory groove meningioma 0 trials
- Optic tract meningioma 0 trials Sub-types →
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Tumor of meninges 1 trial · 123 incl. sub-types
5 sub-types
- Meningioma 108 trials · 122 incl. sub-types Sub-types →
- Malignant tumor of meninges 0 trials · 14 incl. sub-types Sub-types →
- Benign neoplasm of meninges 0 trials · 5 incl. sub-types Sub-types →
- Diffuse leptomeningeal melanocytosis 0 trials
- Familial multiple meningioma 0 trials
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Central nervous system hematopoietic neoplasm 0 trials · 107 incl. sub-types
4 sub-types
- Primary central nervous system lymphoma 92 trials · 103 incl. sub-types Sub-types →
- Central nervous system leukemia 4 trials
- Intracranial cavernous angioma 0 trials
- Pituitary gland basophil adenoma 0 trials
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Spinal cord neoplasm 36 trials · 77 incl. sub-types
8 sub-types
- Spinal cord cancer 21 trials · 57 incl. sub-types Sub-types →
- Childhood spinal cord tumor 1 trial
- Benign neoplasm of spinal cord 0 trials Sub-types →
- Cervicomedullary junction neoplasm 0 trials
- Conus medullaris neoplasm 0 trials
- Neurofibroma of spinal cord 0 trials
- Spinal cord dermoid cyst 0 trials
- Spinal meningioma 0 trials
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Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types
3 sub-types
- Paraganglioma 53 trials · 57 incl. sub-types Sub-types →
- Ganglioneuroma 5 trials Sub-types →
- Sympathetic neurilemmoma 0 trials
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Central nervous system organ benign neoplasm 1 trial · 57 incl. sub-types
13 sub-types
- Craniopharyngioma 29 trials Sub-types →
- Benign neoplasm of brain 16 trials · 21 incl. sub-types Sub-types →
- Benign neoplasm of meninges 0 trials · 5 incl. sub-types Sub-types →
- Central nervous system hemangioma 0 trials · 2 incl. sub-types Sub-types →
- Multinodular and vacuolating neuronal tumor 2 trials
- Diffuse leptomeningeal glioneuronal tumor 1 trial
- Polymorphous low grade neuroepithelial tumor of the young 1 trial
- Benign neoplasm of peripheral nervous system 0 trials Sub-types →
- Benign neoplasm of spinal cord 0 trials Sub-types →
- Central nervous system chondroma 0 trials
- Central nervous system leiomyoma 0 trials
- Central nervous system lipoma 0 trials Sub-types →
- Myxoid glioneuronal tumor 0 trials
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Central nervous system germ cell tumor 6 trials · 9 incl. sub-types
6 sub-types
- Central nervous system germinoma 2 trials · 4 incl. sub-types Sub-types →
- Malignant pineal area germ cell neoplasm 2 trials · 3 incl. sub-types Sub-types →
- Central nervous system nongerminomatous germ cell tumor 2 trials Sub-types →
- Childhood central nervous system germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
- Adult central nervous system germ cell tumor 0 trials Sub-types →
- Mixed germ cell tumor of central nervous system 0 trials Sub-types →
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Epidural abscess 5 trials
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Optic nerve neoplasm 1 trial · 4 incl. sub-types
3 sub-types
- Optic nerve glioma 2 trials · 3 incl. sub-types Sub-types →
- Optic nerve sheath meningioma 1 trial
- Bilateral meningioma of optic nerve 0 trials
Most studied deeper sub-types
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New hope for kids with rare cancers: drug targets tumor growth
Disease control OngoingThis phase 2 trial tests the drug cabozantinib in children and young adults with rare cancers like sarcomas, Wilms tumor, and others that have come back or not responded to treatment. Cabozantinib works by blocking enzymes that help tumors grow and form blood vessels. The study a…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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Engineered immune cells delivered directly to the brain show promise for kids with deadly tumors
Disease control OngoingThis early-stage trial tests a new treatment for children and young adults up to age 21 with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a pro…
Phase 1 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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New hope for kids with tough cancers: entrectinib trial underway
Disease control OngoingThis study tests a drug called entrectinib in children with advanced solid tumors or brain tumors that have come back or haven't responded to other treatments. The trial has two parts: first finding the best dose, then seeing how well it works in children whose tumors have specif…
Phase 1/2 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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New hope for kids with resistant tumors: drug combo enters safety trial
Disease control OngoingThis early-stage study tests a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with advanced or recurrent solid tumors that have specific genetic changes. The main goal is to find the safest dose with the fewest side effects. The…
Phase 1 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New drug shows promise for rare childhood cancers
Disease control OngoingThis study tests a drug called larotrectinib in children and young adults (up to age 30) with certain cancers that have a specific genetic change called a TRK fusion. The goal is to see if the drug can shrink solid tumors or control leukemia that has returned. The drug works by b…
Phase 2 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Brain cancer hope: new drug cocktail targets rare lymphoma
Disease control OngoingThis study tests whether adding lenalidomide or ibrutinib to standard chemotherapy (R-MPV) can improve outcomes for adults aged 18-65 with newly diagnosed primary central nervous system lymphoma. The trial has two parts: first, finding the safest dose, then randomly assigning pat…
Phase 1/2 • Sponsor: Institut Curie • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Choice or fixed? study tests how to get better data from young cancer patients
Knowledge-focused OngoingThis study enrolls 400 adolescents and young adults (ages 18-39) recently diagnosed with various cancers. Participants are randomly assigned to either choose which health-related questions they answer or receive a fixed set of questions. The goal is to see if giving patients a ch…
Early phase 1 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Knowledge-focused
Last updated Sep 06, 2026 00:00 UTC
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Childhood cancer Survivors' sleep under the microscope
Knowledge-focused OngoingThis study looks at sleep problems in adults who had childhood cancer. About 200 survivors of leukemia, brain tumors, or solid tumors will wear sleep monitors and answer questionnaires. The goal is to find out how common sleep disorders are and how they relate to other health iss…
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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Friends and fitness: key to life after cancer?
Knowledge-focused OngoingThis study follows 250 young adult cancer survivors to see how their social relationships and physical activity change over time and how these factors affect their quality of life. Participants wear an activity tracker and complete surveys. The goal is to learn how to better supp…
Sponsor: University of Southern California • Aim: Knowledge-focused
Last updated Aug 02, 2026 00:00 UTC
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Can a text message help young cancer survivors kick the vape habit?
Knowledge-focused OngoingThis study looks at e-cigarette use among 500 teenage and young adult cancer survivors and tests a text-message based program to help them quit. Researchers will also interview patients and healthcare providers to find the best ways to offer this support in oncology clinics. The …
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC