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Celiac disease
MONDO:0005130An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.
Also known as: celiac disease, celiac sprue, coeliac sprue, gluten intolerance, gluten-induced enteropathy, non tropical sprue
121 clinical trials for this condition and its sub-types, 81 tagged with Celiac disease itself.
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Sub-types of Celiac disease
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Lane Hamilton syndrome 0 trials
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Iron infusions may boost gut healing in celiac disease
Disease control Stopped earlyThis trial investigates whether adding intravenous iron to standard oral iron supplements can help heal intestinal damage in people with celiac disease who have iron deficiency and gut atrophy. Participants receive either intravenous iron infusions plus oral iron, or oral iron al…
Phase 4 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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New drug aims to tame gluten reaction in celiac disease
Disease control Stopped earlyThis study tested an experimental drug called KAN-101 in people with celiac disease. The goal was to see if it could safely reduce the immune response to gluten. The trial included 128 participants and was split into phases to check safety and how the body processes the drug. How…
Phase 1/2 • Sponsor: Kanyos Bio, Inc., a wholly-owned subsidiary of Anokion SA • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC