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CDKL5 disorder

MONDO:0100039

A monogenic disease that has material basis in mutation in the CDKL5 gene.

Also known as: CDKL5 Deficiency Disorder, CDKL5 disorder, CDKL5 inherited genetic disease, inherited genetic disease caused by mutation in CDKL5, CDKL5, CDKL5-related disorder

9 clinical trials for this condition and its sub-types.

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Sub-types

Developmental and epileptic encephalopathy, 2 (8)

Broader categories

Disease (618) Hereditary disease (172) Human disease (14) Disease of genetic or genomic mechanism (2) Disease by etiologic mechanism (0)

Not yet recruiting 2 Not yet finished but already full! 3 Completed 3 Terminated 1

New drug shows promise for Tough-to-Treat seizures in kids

Disease control Terminated

This study looked at the long-term safety of soticlestat, an experimental drug, in children and adults with severe forms of epilepsy like Dravet syndrome and Lennox-Gastaut syndrome. Participants took soticlestat twice a day along with their usual seizure medicines. The study was…

Phase: PHASE2 • Sponsor: Takeda • Aim: Disease control

Last updated Jun 27, 2026 11:03 UTC

CDKL5 disorder

Sub-types

Broader categories

New drug shows promise for Tough-to-Treat seizures in kids