CDKL5 disorder
MONDO:0100039A monogenic disease that has material basis in mutation in the CDKL5 gene.
Also known as: CDKL5 Deficiency Disorder, CDKL5 disorder, CDKL5 inherited genetic disease, inherited genetic disease caused by mutation in CDKL5, CDKL5, CDKL5-related disorder
11 clinical trials for this condition and its sub-types, 8 tagged with CDKL5 disorder itself.
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Sub-types of CDKL5 disorder
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New drug trial aims to tame seizures in rare childhood disorder
Disease control Not yet recruitingThis study tests whether the drug ganaxolone can reduce seizures in children aged 6 months to 2 years with CDKL5 deficiency disorder, a rare genetic condition causing hard-to-control seizures. Twenty children will receive either ganaxolone or a placebo alongside their usual seizu…
Phase 3 • Sponsor: Immedica Pharma AB • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Hot baths tested as seizure treatment for rare childhood disorder
Symptom relief Not yet recruitingThis study tests whether taking a daily hot bath (40-42°C for 20 minutes) at home can reduce epileptic seizures in children with CDKL5 deficiency disorder. The trial will include 34 children aged 6 months to 14 years whose seizures are not controlled by medication. Researchers wi…
Sponsor: Xuanwu Hospital, Beijing • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC