C-cell hyperplasia
MONDO:0006120Neoplastic or reactive proliferation of the C-cells in the thyroid gland. The neoplastic C-cell hyperplasia is associated with familial medullary thyroid gland carcinoma and multiple endocrine neoplasia type II and IIB. Morphologically, it is characterized by the presence of clusters of intrafollicular C-cells with atypical cytologic features. The reactive C-cell hyperplasia is also known as physiological or secondary C-cell hyperplasia and it is associated with conditions that cause hypercalcemia (e.g., hyperparathyroidism).
Also known as: C-cell hyperplasia
26 clinical trials for this condition and its sub-types.
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Could a tiny surgical patch preserve your voice after thyroid removal?
Symptom relief CompletedThis trial investigates whether placing a small piece of absorbable material (oxidized regenerated cellulose) over the nerves that control the voice box during total thyroidectomy can improve early voice quality. Thirty adults scheduled for thyroid surgery will be randomly assign…
Phase: NA • Sponsor: Ankara University • Aim: Symptom relief
Last updated Jul 04, 2026 00:00 UTC
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No-Drain thyroid surgery shows promise for benign nodules
Symptom relief CompletedThis study looked at whether removing benign thyroid nodules without placing a surgical drain is safe and effective. Eighty adults having thyroid surgery were randomly assigned to either the standard drain or a no-drain, sutureless technique. The goal was to see if the no-drain a…
Phase: NA • Sponsor: Minia University • Aim: Symptom relief
Last updated Jun 27, 2026 13:02 UTC
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Water jet technique shields voice nerve in thyroid surgery
Symptom relief CompletedThis study tested a new method called the 'Huaxi Tunnel Technique' to protect the recurrent laryngeal nerve during thyroid surgery. The technique uses a diluted epinephrine solution injected along the nerve to create a protective tunnel, reducing the risk of injury. The trial inv…
Phase: NA • Sponsor: West China Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Glow-in-the-Dark dye could help surgeons avoid nerves
Knowledge-focused CompletedThis small study tested whether injecting a fluorescent dye called fluorescein sodium helps surgeons see nerves during head and neck surgery. Eight adults having open head or neck surgery received the dye through an IV. Surgeons then rated how well the glowing nerves matched stan…
Phase: PHASE2 • Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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Researchers measure breathing, strength, and quality of life in hospitalized endocrine patients
Knowledge-focused CompletedThis completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…
Sponsor: Uşak University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Blood samples aim to harmonize thyroid testing worldwide
Knowledge-focused CompletedThis completed study collected extra blood samples from 28 adults with thyroid disorders to help standardize thyroid-stimulating hormone (TSH) tests. Different labs often use different tests, making it hard to compare results. By analyzing these samples, researchers hope to make …
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:14 UTC