Brain edema
MONDO:0006684Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see hypoxia, brain). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of csf flow (e.g., obstructive hydrocephalus). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
22 clinical trials for this condition and its sub-types.
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New drug aims to tame brain swelling after bleeding stroke
Disease control OngoingThis study tests an experimental drug called MW189 in 120 adults who have had a brain bleed (intracerebral hemorrhage). The goal is to see if the drug is safe and can reduce brain swelling. Participants receive the drug within 24 hours of their stroke and are monitored for side e…
Phase: PHASE2 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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AI boosts brain scan accuracy in massive new trial
Diagnosis ENROLLING_BY_INVITATIONThis study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…
Sponsor: Yaou Liu • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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Massive review seeks to uncover hidden dangers of severe low sodium
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks back at the medical records of 800 people who were hospitalized with dangerously low sodium levels (≤110 mmol/L). Researchers want to learn how often serious brain complications like swelling or nerve damage occur, and how treatment affects these risks. No new tr…
Sponsor: Rochester General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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New computer protocol aims to protect lungs and brains of injured patients
Knowledge-focused OngoingThis study looks at whether a computer-guided breathing machine (ventilator) protocol can help patients with serious brain injuries. The goal is to use low air volumes to protect the lungs while keeping carbon dioxide levels normal to protect the brain. About 728 adults on ventil…
Phase: NA • Sponsor: Colin Grissom • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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AI could spot deadly brain swelling before It's too late
Knowledge-focused OngoingThis study tests whether artificial intelligence can predict malignant brain edema, a life-threatening swelling, in patients who have had a major stroke. Researchers will analyze CT scans and clinical data from over 1,600 patients to see if the AI can identify early warning signs…
Sponsor: University Hospital Tuebingen • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:17 UTC
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300 volunteers help create medical image bank for science
Knowledge-focused OngoingThis study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…
Sponsor: Mario Negri Institute for Pharmacological Research • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:28 UTC