Autoimmune disorder of the nervous system

MONDO:0002977

A disorder characterized by the degeneration of the nervous system due to autoimmunity. Representative examples include multiple sclerosis, Guillain-Barre syndrome, and myasthenia gravis.

Also known as: autoimmune disease of nervous system, autoimmune disease, neurologic, autoimmune diseases, nervous system, autoimmune diseases, neurologic, autoimmune disorders of the nervous system, autoimmune disorders, nervous system, autoimmune nervous system diseases, autoimmune nervous system disorder

1101 clinical trials for this condition and its sub-types, 47 tagged with Autoimmune disorder of the nervous system itself.

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Where it sits in the disease tree

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Part of

↑ Nervous system disorder (26669) ↑ Autoimmune disease (4049)

Sub-types of Autoimmune disorder of the nervous system

Autoimmune disorder of central nervous system 2 trials · 881 incl. sub-types
8 sub-types
- Multiple sclerosis 770 trials · 858 incl. sub-types Sub-types →
- Autoimmune encephalitis 32 trials · 33 incl. sub-types Sub-types →
- Central nervous system lupus 3 trials
- Autoimmune epilepsy 1 trial
- Miller Fisher syndrome 0 trials
- Autoimmune encephalopathy with parasomnia and obstructive sleep apnea 0 trials
- Autoimmune optic neuritis 0 trials
- Primary hypophysitis 0 trials Sub-types →
Autoimmune disorder of peripheral nervous system 0 trials · 195 incl. sub-types
4 sub-types
- Myasthenia gravis 159 trials · 160 incl. sub-types Sub-types →
- Guillain-Barre syndrome 23 trials · 39 incl. sub-types Sub-types →
- Autoimmune neuropathy 1 trial
- Autoimmune optic neuritis 0 trials
Pediatric acute-onset neuropsychiatric syndrome 8 trials · 10 incl. sub-types
1 sub-type
- PANDAS 6 trials
Autoimmune retinopathy 0 trials

Most studied deeper sub-types

Relapsing-remitting multiple sclerosis (265) Chronic progressive multiple sclerosis (83) Secondary progressive multiple sclerosis (66) Primary progressive multiple sclerosis (59) Polyneuropathy, inflammatory demyelinating, chronic (15) Pediatric multiple sclerosis (5) Juvenile myasthenia gravis (2) Acute inflammatory demyelinating polyradiculoneuropathy (1) Autoimmune autonomic ganglionopathy (1) Autoimmune limbic encephalitis (1) Guillain-Barre syndrome, familial (1) Progressive relapsing multiple sclerosis (1) Acute motor and sensory axonal neuropathy (0) Acute motor axonal neuropathy (0) Acute pure sensory neuropathy (0) Acute sensory ataxic neuropathy (0) Adenohypophysitis (0) Adult-onset myasthenia gravis (0) Facial diplegia with paresthesias (0) Infundibulo-neurohypophysitis (0)

Including sub-types (1101) Tagged with Autoimmune disorder of the nervous system (47)

Trials to join now! 25 Not yet recruiting 7 Not yet finished but already full! 6 Completed 8 Terminated 1

Melatonin trial for MS halted early – what we know

Disease control Stopped early

This study tested whether adding melatonin to the standard drug ocrelizumab could safely slow disability in people with progressive primary multiple sclerosis. The trial was terminated early, so results are limited. Participants were adults aged 18–65 with this type of MS.

Phase 1/2 • Sponsor: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla • Aim: Disease control

Last updated Jun 27, 2026 09:06 UTC

Autoimmune disorder of the nervous system

Where it sits in the disease tree

Most studied deeper sub-types

Melatonin trial for MS halted early – what we know