Aquagenic pruritus

MONDO:0021913

Aquagenic pruritus is a conditionin which contact with water of any temperature causes intense itching, without any visible skin changes. The symptoms may begin immediately after contact and can last for an hour or more. The cause of aquagenic pruritus is unknown; however, familial cases have been described. It may be a symptom of polycythemia vera or another underlying condition. Overall, treatment is a challenge. Antihistamines, UVB phototherapy, PUVA therapy and various medications have been tried with varying degrees of success.

Also known as: aquagenic pruritus, water-induced itching

1 clinical trial for this condition and its sub-types, 1 tagged with Aquagenic pruritus itself.

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Where it sits in the disease tree

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Including sub-types (1) Tagged with Aquagenic pruritus (1)

Completed 1

Itch relief showdown: which drug stops water-induced agony?

Symptom relief Completed

This study tested two oral medications, aprepitant and hydroxyzine, to see which better reduces severe itching triggered by water contact in people with myeloproliferative neoplasms (a type of blood cancer). 63 participants who had persistent itching rated 5 or higher on a 10-poi…

Phase 3 • Sponsor: University Hospital, Brest • Aim: Symptom relief

Last updated Jun 27, 2026 08:01 UTC

Aquagenic pruritus

Where it sits in the disease tree

Itch relief showdown: which drug stops water-induced agony?