Anal squamous cell carcinoma
MONDO:0006082A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC.
Also known as: anal squamous cell cancer, anal squamous cell carcinoma, anus squamous cell carcinoma, epidermoid anal carcinoma, epidermoid carcinoma of anus, epidermoid carcinoma of the anus, squamous cell anal carcinoma, squamous cell carcinoma - anus
2931 clinical trials for this condition and its sub-types, 40 tagged with Anal squamous cell carcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Anal squamous cell carcinoma
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Anal canal squamous cell carcinoma 12 trials
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Anal margin squamous cell carcinoma 4 trials
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Anus basaloid carcinoma 3 trials
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Anal verrucous carcinoma 0 trials
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New hope for Hard-to-Treat anal and rectal cancers
Disease control Not yet recruitingThis study tests a drug called sacituzumab tirumotecan in 20 people with advanced anal or rectal cancer that has spread or cannot be removed and has not responded to other treatments. The goal is to see if the drug can shrink tumors and how safe it is. Participants will receive t…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Drug combo aims to shrink Hard-to-Treat anal cancer
Disease control Not yet recruitingThis phase 2 trial tests whether the combination of pembrolizumab (an immunotherapy) and lenvatinib (a targeted therapy) can shrink tumors in people with advanced anal squamous cell cancer that cannot be removed by surgery or has spread to other organs. Participants must have alr…
Phase 2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
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Can training clinics to be less stigmatizing boost HIV prevention?
Knowledge-focused Not yet recruitingThis study tests whether training healthcare providers to reduce stigma can increase the use of HIV and STI prevention services, like testing and preventive medications. It will involve 8 clinics in the Mississippi Delta and track changes in how often patients receive these servi…
Sponsor: Albert Einstein College of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC