Allan-Herndon-Dudley syndrome
MONDO:0010354A syndrome with neuromuscular involvement characterized by infantile hypotonia, muscular hypoplasia, spastic paraparesis with dystonic/athetoic movements, and severe cognitive deficiency.
Also known as: AHDS, ALLAN-Herndon syndrome, Allan-Herndon-Dudley syndrome, MCT8 deficiency, MCT8-Specific Thyroid Hormone Cell Transporter Deficiency, MCT8-specific thyroid hormone cell Membrane transporter deficiency, X-linked intellectual disability-hypotonia syndrome, monocarboxylate transporter 8 deficiency
34 clinical trials for this condition and its sub-types.
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Experimental drug shows promise for rare genetic syndrome in toddlers
Disease control OngoingThis phase 2 trial tests the drug tiratricol (Triac) in 22 young boys (up to 30 months old) with MCT8 deficiency, also known as Allan-Herndon-Dudley syndrome. The goal is to see if the drug can improve brain development and reduce harmful thyroid effects in the body. Participants…
Phase: PHASE2 • Sponsor: Rare Thyroid Therapeutics International AB • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Virtual reality could calm anxious kids with autism at the dentist
Symptom relief ENROLLING_BY_INVITATIONThis study tests whether wearing a virtual reality (VR) headset during dental treatment can reduce fear and stress in children with mild intellectual disabilities or autism spectrum disorder. Two hundred children aged 6 to 12 will either receive standard dental care or use a VR h…
Phase: NA • Sponsor: Semmelweis University • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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Robot suit helps kids with movement disorders take steps at home
Symptom relief OngoingThis study tests a wearable robotic exoskeleton called EXPLORER in 15 children with movement problems from conditions like cerebral palsy. The goal is to see if it helps them walk better in their everyday environments, such as home and the community. The study focuses on safety, …
Phase: NA • Sponsor: MarsiBionics • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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New framework aims to prevent medication errors in vulnerable group
Knowledge-focused OngoingThis study works with 110 adults who have intellectual or developmental disabilities and receive care from a Norwegian municipality. The goal is to create better routines and digital tools to make sure they get the right medicines safely. Researchers will review each person's med…
Phase: NA • Sponsor: Vestvagoy Municipality • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC