Please sign in to follow a disease.

Aggressive systemic mastocytosis

MONDO:0020333

Aggressive systemic mastocytosis (ASM) is a severe and rare form of systemic mastocytosis (SM) characterized by considerable infiltration of mast cells in different tissues.

Also known as: ASM, aggressive systemic mastocytosis (morphologic abnormality)

1857 clinical trials for this condition and its sub-types, 4 tagged with Aggressive systemic mastocytosis itself.

Follow this condition to get notified about new trials

Where it sits in the disease tree

Browse by category →

Part of

↑ Systemic mastocytosis (24)

Sub-types of Aggressive systemic mastocytosis

Lymphoadenopathic mastocytosis with eosinophilia 0 trials

Including sub-types (1857) Tagged with Aggressive systemic mastocytosis (4)

Trials to join now! 2 Not yet finished but already full! 1 Completed 1

New hope for tough blood cancers: experimental drug MGD024 enters human testing

Disease control Ongoing

This early-stage study tests a new drug called MGD024 in people with certain blood cancers (like leukemia and lymphoma) that came back or didn't get better with standard treatments. The main goal is to find the safest dose and watch for side effects. About 130 adults will receive…

Phase 1 • Sponsor: MacroGenics • Aim: Disease control

Last updated Jul 30, 2026 00:00 UTC

Aggressive systemic mastocytosis

Where it sits in the disease tree

New hope for tough blood cancers: experimental drug MGD024 enters human testing