Adenoid cystic carcinoma
MONDO:0004971A malignant tumor arising from the epithelial cells. Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma). Adenoid cystic carcinomas mostly occur in the salivary glands. Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs. Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur. Lymph node metastases are unusual; hematogenous tumor spread is characteristic.
Also known as: adenocystic carcinoma, adenoid cystic cancer, adenoid cystic carcinoma, cylindroid adenocarcinoma, cribriform carcinoma, cylindroma
2792 clinical trials for this condition and its sub-types, 47 tagged with Adenoid cystic carcinoma itself.
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Sub-types of Adenoid cystic carcinoma
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2 sub-types
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2 sub-types
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Adenoid cystic breast carcinoma 0 trials
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Cervical adenoid cystic carcinoma 0 trials
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Cutaneous adenocystic carcinoma 0 trials
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Esophageal adenoid cystic carcinoma 0 trials
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Laryngeal adenoid cystic carcinoma 0 trials
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Lung adenoid cystic carcinoma 0 trials
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Lymph node adenoid cystic carcinoma 0 trials
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Pharyngeal adenoid cystic carcinoma 0 trials
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Prostate adenoid cystic carcinoma 0 trials
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Tracheal adenoid cystic carcinoma 0 trials
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Vaginal adenoid cystic carcinoma 0 trials
Most studied deeper sub-types
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New pill-chemo combo takes on hard-to-treat cancers
Disease control Not yet recruitingThis study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …
Phase 1/2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Sep 21, 2026 21:00 UTC
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New drug hope for rare throat and thyroid cancers
Disease control Not yet recruitingThis study tests a drug called sacituzumab tirumotecan in people with two rare cancers: adenoid cystic carcinoma (a type of salivary gland cancer) and papillary thyroid carcinoma that have returned or spread. About 68 participants will receive the drug through an IV twice a month…
Phase 2 • Sponsor: National Cancer Centre, Singapore • Aim: Disease control
Last updated Jul 17, 2026 00:00 UTC
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New targeted pill holds promise for rare salivary gland cancer that spreads
Disease control Not yet recruitingThis phase 2 trial tests the drug zanzalintinib in people whose adenoid cystic carcinoma (a rare salivary gland cancer) has returned or spread. Despite initial surgery and radiation, about half of patients experience recurrence, and current treatments offer limited benefit. Parti…
Phase 2 • Sponsor: UNICANCER • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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Promising drug cocktail aims to shrink aggressive nasal tumors before surgery
Disease control Not yet recruitingThis study tests whether giving a combination of anlotinib (a targeted therapy) and epirubicin (chemotherapy) before surgery can improve outcomes for people with advanced sinonasal adenoid cystic carcinoma, a rare and aggressive cancer of the nasal cavity and sinuses. About 76 pa…
Phase 2 • Sponsor: Eye & ENT Hospital of Fudan University • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New combo therapy takes aim at Hard-to-Treat salivary gland cancer
Disease control Not yet recruitingThis phase II trial tests a combination of an antibody-drug conjugate (a targeted cancer drug) and stereotactic body radiotherapy (precise, high-dose radiation) in 40 people with recurrent or metastatic salivary gland cancer. Participants first receive the drug; if their disease …
Phase 2 • Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Radiation-Free hope: study tests if surgery alone is enough for rare nasal cancer
Disease control Not yet recruitingThis study looks at whether patients with a rare nasal cancer (sinonasal adenoid cystic carcinoma) can safely avoid radiation after surgery if the tumor was completely removed. About 200 patients will choose either surgery alone or surgery plus radiation, and researchers will tra…
Sponsor: Eye & ENT Hospital of Fudan University • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC