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Activated PI3K-delta syndrome

MONDO:0018338

Also known as: APDS, senescent T-cells-lymphadenopathy-immunodeficiency syndrome due to p110delta-activating mutation

47 clinical trials for this condition and its sub-types.

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Sub-types

Immunodeficiency 14 (6) Immunodeficiency 36 with lymphoproliferation (0)

Broader categories

Disease (680) Hereditary disease (176) Hematologic disorder (170) Immune system disorder (148) Inborn error of immunity (118) Immunodeficiency disease (54) Agammaglobulinemia (15) Human disease (14) Leukocyte disorder (6) B cell deficiency (5)

Trials to join now! 23 Not yet recruiting 7 Not yet finished but already full! 7 Completed 9 Terminated 1

Experimental drug shows promise for rare immune disorder, but study cut short

Disease control Terminated

This study tested the long-term safety and effectiveness of a drug called CDZ173 in people with APDS/PASLI, a rare genetic condition that causes a weak immune system and swollen lymph nodes. The 37 participants had already taken CDZ173 or a similar drug in a previous study. The t…

Phase: PHASE2, PHASE3 • Sponsor: Pharming Technologies B.V. • Aim: Disease control

Last updated Jun 27, 2026 12:01 UTC