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Activated PI3K-delta syndrome

MONDO:0018338

Also known as: APDS, senescent T-cells-lymphadenopathy-immunodeficiency syndrome due to p110delta-activating mutation

47 clinical trials for this condition and its sub-types, 5 tagged with Activated PI3K-delta syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Agammaglobulinemia (52)

Sub-types of Activated PI3K-delta syndrome

Immunodeficiency 14 6 trials
Immunodeficiency 36 with lymphoproliferation 0 trials

Including sub-types (47) Tagged with Activated PI3K-delta syndrome (5)

Trials to join now! 1 Not yet finished but already full! 3 Terminated 1

Experimental drug shows promise for rare immune disorder, but study cut short

Disease control Stopped early

This study tested the long-term safety and effectiveness of a drug called CDZ173 in people with APDS/PASLI, a rare genetic condition that causes a weak immune system and swollen lymph nodes. The 37 participants had already taken CDZ173 or a similar drug in a previous study. The t…

Phase 2/3 • Sponsor: Pharming Technologies B.V. • Aim: Disease control

Last updated Jun 27, 2026 12:01 UTC