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127005 trials found · Page 6345 of 6351
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A randomised, Double-Blind, Placebo-Controlled, single dose trial evaluating different doses of intravenously administered VMX-C001 and to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of VMX-C001 in healthy subjects (Part 1) and in combination with a selected FXa direct oral anticoagulant (DOAC) in healthy older subjects (Part 2)
CompletedA single centre, double-blind, randomized, placebo-controlled single dose study to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of VMX-C001, conducted in two parts: Part 1: Single dose of VMX-C001 or placebo in healthy volunteers. Part 2: Sin…
Phase 1 • Sponsor: VarmX B.V.
Last updated Sep 09, 2026 16:00 UTC
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A pharmacokinetic study of NTI164 in healthy adult volunteers
CompletedThis study is looking at how a new cannabis compound with extremely low THC (0.08%), NTI164, is metabolised in the body and how it is excreted in urine over time (up to 28 days) in healthy adult volunteers. NTI164 will be delivered twice daily, at a concentration of 20mg/kg/day. …
Phase 1 • Sponsor: Fenix Innovation Group
Last updated Sep 09, 2026 16:00 UTC
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Prospective comparative cohort study of premium versus economy cabin travel and popliteal vein diameter after Long-Haul flight after an aesthetic surgery
Recruiting nowThis prospective cohort study will compare popliteal vein diameter changes in international travelers who independently fly to Bogota in premium business/first class or economy class. Standardized bilateral ultrasound will be performed before flight, within 2 hours after arrival,…
Sponsor: Research Inc
Last updated Sep 09, 2026 16:00 UTC
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Prospective stratified randomized Four-Group study of cabin class and graduated compression stockings on popliteal vein dilation after Long-Haul air travel after aesthetic surgery
Recruiting nowThis four-group prospective study will enroll travelers who have independently booked economy or premium business/first-class flights to Bogota. Within each cabin stratum, participants will be randomized to moderate graduated compression stockings or no stockings. Bilateral popli…
Sponsor: Research Inc
Last updated Sep 09, 2026 16:00 UTC
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Randomized Assessor-Masked trial of moderate graduated compression stockings for popliteal vein dilation during Long-Haul Economy-Class air travel after aesthetic surgery
Recruiting nowThis randomized assessor-masked trial will evaluate whether knee-high moderate graduated compression stockings reduce popliteal vein dilation during long-haul economy-class air travel to Bogota. Participants will be assigned to stockings or no stockings and will undergo bilateral…
Sponsor: Research Inc
Last updated Sep 09, 2026 16:00 UTC
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Multicenter study to evaluate the efficacy, safety, immunogenicity, and pharmacokinetics of recombinant human coagulation factor Ⅷ-Fc fusion protein (FRSW117) for injection in patients with severe hemophilia a (Adults and adolescents)
CompletedTo evaluate the prophylactic efficacy of recombinant human coagulation factor Ⅷ-Fc fusion protein (FRSW117) for injection in patients with severe hemophilia A. To evaluate the safety of recombinant human coagulation factor Ⅷ-Fc fusion protein (FRSW117) for injection in patients …
Phase 3 • Sponsor: Hangzhou Gensciences Biopharmaceutical Co., Ltd.
Last updated Sep 09, 2026 16:00 UTC
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Optimizing low-dose contrast media protocol for Low-kVp abdominopelvic CT in suspected acute appendicitis
Stopped earlyThe purpose of this clinical study is to test the performance of low radiation dose abdominal CT combined with low dose contrast media for the diagnosis of acute appendicitis in young patients. The main questions to be answered are: 1. Can low-dose contrast media paired with low…
Sponsor: Bohyun Kim
Last updated Sep 09, 2026 16:00 UTC
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"Impact of NOciception level (NOL) index intraoperative guidance of REmifentanil administration on opioid consumption and QoR in ambulatory patients undergoing LAparoscopic cholecystectomy. a randomized controlled trial"
CompletedBackground: Laparoscopic cholecystectomy is a common surgical procedure which constitutes the standard treatment for symptomatic gallbladder disease. Elective procedures are performed as outpatient surgery due to the minimally invasive technique, fast recovery and low complicatio…
Sponsor: Svendborg Hospital
Last updated Sep 09, 2026 16:00 UTC
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A Proof-of-Concept study: the personalized creation of immersive virtual environments to promote emotional well-being in older adults
CompletedBackground: Virtual Reality (VR) technology has seen a growing adoption in clinical and healthcare settings. VR applications are both effective and acceptable, with a great potential for populations with mobility restrictions, such as older adults receiving home-based care or in …
Sponsor: University of Vic - Central University of Catalonia
Last updated Sep 09, 2026 16:00 UTC
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Comparison between pads with cold solution of magnesium sulfate or cold water to treat pain and improve healing of the perineum after vaginal delivery. a prospective, randomized, double-blind controlled study.
CompletedPerineal pain after delivery is common and is caused by local bruising or episiotomy. The pain may last for several days or months. Thus, several analgesic methods are offered. Topical magnesium sulfate 33% solution is a common treatment for perineal pain, wound treatment and all…
Phase 4 • Sponsor: The Baruch Padeh Medical Center, Poriya
Last updated Sep 09, 2026 16:00 UTC
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Lactobacillus rhamnosus GG alleviates oral mucositis in patients undergoing radiotherapy for malignant head and neck tumors: a randomized controlled trial
CompletedRadiation therapy is a common treatment modality in the management of head and neck malignancies. However, head and neck tumors often have some adverse reactions when receiving radiation therapy, such as dry mouth, change of taste, oral mucositis, etc. Among them, the incidence o…
Phase 2 • Sponsor: West China Hospital
Last updated Sep 09, 2026 16:00 UTC
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A phase II/III randomized clinical trial of CisPlatin plUs gemcitabine and nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY tract cancers (BTC) at high risk for recurrence: PURITY study
Recruiting nowPURITY is a multicentre, randomized adaptive phase II/III trial aimed at comparing the triplet combination of gemcitabine, cisplatin and nabpaclitaxel as neoadjuvant treatment (ARM A) versus standard upfront surgery (ARM B) in terms of 12-month PFS rate (phase II part) and PFS (p…
Phase 2/3 • Sponsor: Gruppo Oncologico del Nord-Ovest
Last updated Sep 09, 2026 16:00 UTC
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Investigating the Mu:Kappa opioid receptor imbalance in alcohol use disorder
Recruiting nowThe primary objective of this multimodal positron emission tomography (PET) study is to use PET brain imaging to measure both MOR (Mu-Opioid receptors) and KOR (kappa-opioid receptors) in participants with alcohol use disorder (AUD) and to quantify the relationships between MOR a…
Early phase 1 • Sponsor: Yale University
Last updated Sep 09, 2026 16:00 UTC
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Department of hematology, the second affiliated hospital of kunming medical university.
CompletedCombining the results of previous studies and based on the clinical practice in our center, we designed the Venetoclax in combination with 3days-Decitabine regimen for induction therapy in elderly or unfit AML patients with a primary diagnosis, and set Venetoclax in combination w…
Phase 3 • Sponsor: The Second Affiliated Hospital of Kunming Medical University
Last updated Sep 09, 2026 16:00 UTC
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Dynamic versus static night splinting of plantar fasciitis
Stopped earlyThe investigators are trying to study that there is no difference in improvement of motion between static progressive and dynamic splinting.
Sponsor: Stanford University
Last updated Sep 09, 2026 16:00 UTC
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Assessing the safety and efficacy of Full-Spectrum medicinal cannabis plant extract 0.08% THC (NTI164) in the treatment of rett syndrome (RTT)
CompletedThis 18-week open-label study examines the effectiveness of Full-Spectrum Medicinal Cannabis Plant Extract containing 0.08% THC (NTI164) in treating Rett syndrome (RTT) in children and young people. The study aims to determine the impact of NTI164 on RTT symptoms over a 16-week t…
Phase 1/2 • Sponsor: Fenix Innovation Group
Last updated Sep 09, 2026 16:00 UTC
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Prevention of thromboembolism using apixaban vs enoxaparin following spinal cord injury
Recruiting nowCurrently, Enoxaparin is the usual prophylactic anticoagulant treatment at the acute and sub-acute phases of spinal cord injury (SCI). Patients at the sub-acute phase of SCI (rehabilitation) will be given either Enoxaparin 40 mg/day (control) or Apixaban 2.5-5 mg twice a day. Api…
Sponsor: Loewenstein Hospital
Last updated Sep 09, 2026 16:00 UTC
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Eradication of helicobacter pylori: a comparative randomized controlled trial of bismuth quadruple therapy and bismuth add-on to clarithromycin triple therapy
CompletedThe primary objective of the study is to compare the efficacy of 2 different regimens of treatment of gastric bacteria (H pylori) these are: quadruple bismuth therapy and clarithromycin triple therapy with add-on bismuth, in eradicating H. pylori. The secondary objective of the …
Phase 3 • Sponsor: Reham Abdelkader Elkhouly
Last updated Sep 09, 2026 16:00 UTC
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A prospective imaging study of target definition and radiation planning workflows on the integrated TrueBeam-HyperSight system for patients receiving radiation therapy
OngoingCone beam computed tomography (CBCT) images are routinely used in radiation treatment delivery workflows to align patients with the treatment beam. Conventional CBCT image quality is sufficient for this task but not good enough for other radiotherapy-related tasks, such as contou…
Sponsor: Varian, a Siemens Healthineers Company
Last updated Sep 09, 2026 16:00 UTC
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A double-blinded, randomized, placebo-controlled phase II trial to assess extended safety and tolerability of subcutaneous CAP256V2LS and VRC07-523LS in HIV negative women
CompletedA double blinded, Randomized, Placebo- controlled phase II trial to assess extended safety and tolerability of subcutaneous CAP256V2LS and VRC07-523LS in HIV- negative women
Phase 2 • Sponsor: Centre for Infectious Disease Research in Zambia
Last updated Sep 09, 2026 16:00 UTC