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Up to: Inherited neurodegenerative disorder

Leukodystrophy

Leukodystrophies are a group of rare, progressive, metabolic, genetic diseases that affect the brain, spinal cord and often the peripheral nerves. Each type of leukodystrophy is caused by a specific gene abnormality that leads to abnormal development or destruction of the white matter (myelin sheath) of the brain. The myelin sheath is the protective covering of the nerve and nerves can't function normally without it. Each type of leukodystrophy affects a different part of the myelin sheath, leading to a range of neurological problems.

6 trials tagged with this condition →

Metachromatic leukodystrophy 20 trials Sub-types →
Adrenoleukodystrophy 19 trials · 20 incl. sub-types Sub-types →
Krabbe disease 15 trials Sub-types →
Aicardi-Goutieres syndrome 9 trials Sub-types →
Pelizaeus-Merzbacher spectrum disorder 8 trials Sub-types →
Peroxisome biogenesis disorder 4 trials · 8 incl. sub-types Sub-types →
Leukoencephalopathy with vanishing white matter 7 trials Sub-types →
Canavan disease 6 trials Sub-types →
Cerebrotendinous xanthomatosis 6 trials
Leukoencephalopathy, diffuse hereditary, with spheroids 1 6 trials
Alexander disease 5 trials Sub-types →
Sjogren-Larsson syndrome 3 trials
Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome 3 trials
Leukodystrophy, demyelinating, adult-onset 0 trials · 3 incl. sub-types Sub-types →
Hypomyelinating leukodystrophy 5 2 trials
Hypomyelinating leukodystrophy 6 2 trials
Hypomyelination with brain stem and spinal cord involvement and leg spasticity 2 trials
Megalencephalic leukoencephalopathy with subcortical cysts 2 trials Sub-types →
Pelizaeus-Merzbacher-like disease 1 trial · 2 incl. sub-types Sub-types →
POLR-related leukodystrophy 0 trials · 2 incl. sub-types Sub-types →
Sterol carrier protein 2 deficiency 1 trial
AARS1-related leukoencephalopathy 0 trials Sub-types →
CADDS 0 trials
Adult-onset progressive leukoencephalopathy-early-onset deafness 0 trials
Alkaline ceramidase 3 deficiency 0 trials
C11orf73-related autosomal recessive hypomyelinating leukodystrophy 0 trials
Cystic leukoencephalopathy without megalencephaly 0 trials
Dermatoleukodystrophy 0 trials
Early-onset calcifying leukoencephalopathy-skeletal dysplasia 0 trials
Episodic memory defect leukoencephalopathy 0 trials
Hereditary spastic paraplegia 2 0 trials
Hypomyelinating leukodystrophy 10 0 trials
Hypomyelinating leukodystrophy 12 0 trials
Hypomyelinating leukodystrophy 13 0 trials
Hypomyelinating leukodystrophy 9 0 trials
Leukodystrophy, adult-onset, autosomal dominant, without amyloid angiopathy 0 trials
Leukodystrophy, childhood-onset, remitting 0 trials
Leukodystrophy, hypomyelinating, 14 0 trials
Leukodystrophy, hypomyelinating, 15 0 trials
Leukodystrophy, hypomyelinating, 16 0 trials
Leukodystrophy, hypomyelinating, 17 0 trials
Leukodystrophy, hypomyelinating, 18 0 trials
Leukodystrophy, hypomyelinating, 19, transient infantile 0 trials
Leukodystrophy, hypomyelinating, 20 0 trials
Leukodystrophy, hypomyelinating, 22 0 trials
Leukodystrophy, hypomyelinating, 23, with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy 0 trials
Leukodystrophy, hypomyelinating, 24 0 trials
Leukodystrophy, hypomyelinating, 25 0 trials
Leukodystrophy, hypomyelinating, 26, with chondrodysplasia 0 trials
Leukodystrophy, hypomyelinating, 28 0 trials
Leukoencephalopathy with bilateral anterior temporal lobe cysts 0 trials
Leukoencephalopathy with mild cerebellar ataxia and white matter edema 0 trials
Leukoencephalopathy without lacunae, adult-onset 0 trials
Leukoencephalopathy, porphyria-related 0 trials
Leukoencephalopathy-thalamus and brainstem anomalies-high lactate syndrome 0 trials
Multiple mitochondrial dysfunctions syndrome 4 0 trials
Neurodevelopmental disorder with microcephaly, epilepsy, and hypomyelination 0 trials
Non-progressive predominantly posterior cavitating leukoencephalopathy with peripheral neuropathy 0 trials
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephaly 0 trials Sub-types →
Progressive cavitating leukoencephalopathy 0 trials
Progressive encephalopathy with leukodystrophy due to DECR deficiency 0 trials
Ravine syndrome 0 trials
Ribose-5-P isomerase deficiency 0 trials
Spastic ataxia 8, autosomal recessive, with hypomyelinating leukodystrophy 0 trials
Unknown leukodystrophy 0 trials