Scientists investigate drug resistance in lung cancer treatment
NCT ID NCT07199959
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This observational study aims to understand how ROS1-positive non-small cell lung cancer develops resistance to the drug entrectinib. Researchers will analyze blood and tissue samples from 38 patients who have already taken entrectinib as part of their regular care. By looking at genetic changes, they hope to identify the mechanisms behind acquired resistance.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fudan university shanghai cancer center
RECRUITINGShanghai, Shanghai Municipality, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Entrectinib
What this could lead to
If successful, this could help doctors understand why some lung cancers stop responding to entrectinib, potentially leading to better treatment strategies.
What could go wrong
This is a small, observational study that only looks back at past data. It won't test new treatments, and findings may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.