New hope for arthritis sufferers: experimental drugs enter human trials

NCT ID NCT06972446

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study tests two experimental drugs, lutikizumab and ravagalimab, alone or together, in about 180 adults with moderate-to-severe rheumatoid arthritis who have not improved with other treatments. The goal is to see if these drugs can reduce joint pain and swelling better than a placebo. Participants will receive injections and be monitored for side effects and disease activity over several months.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AA Medical Research Center - Grand Blanc /ID# 272496
RECRUITING

Grand Blanc, Michigan, 48439, United States
Accurate Clinical Research (SMO/Network/Consortium) /ID# 272650
RECRUITING

Lake Charles, Louisiana, 70605, United States
Accurate Clinical Research - Houston /ID# 272271
RECRUITING

Houston, Texas, 77089-6142, United States
Advanced Clinical Research Center, LLC dba TriWest Research Associates /ID# 277826
RECRUITING

Chula Vista, California, 91910, United States

Contact Phone: •••-•••-••••
Advanced Quality Medical Research /ID# 277824
RECRUITING

Orland Park, Illinois, 60462, United States
Ajou University Hospital - Suwon-si /ID# 273647
RECRUITING

Suwon, Gyeonggido, 16499, South Korea
Albuquerque Center For Rheumatology /ID# 272301
RECRUITING

Albuquerque, New Mexico, 87102, United States
Altoona Center For Clinical Research /ID# 272479
RECRUITING

Duncansville, Pennsylvania, 16635, United States

Contact Phone: •••-•••-••••
Annapolis Rheumatology /ID# 279144
NOT_YET_RECRUITING

Fairfax, Virginia, 22311, United States
Arensia Research Clinic /ID# 280896
NOT_YET_RECRUITING

Phoenix, Arizona, 85015, United States
Arnold Arthritis & Rheumatology /ID# 278354
RECRUITING

Skokie, Illinois, 60076, United States
Arthritis And Rheumatism Associates (Ara) - Jonesboro /ID# 272896
RECRUITING

Jonesboro, Arkansas, 72401, United States
Arthritis Care Of Texas /ID# 277961
RECRUITING

Corpus Christi, Texas, 78415, United States

Contact Phone: •••-•••-••••
Arthritis and Rheumatology Research Institute /ID# 272299
RECRUITING

Allen, Texas, 75013, United States
Biopharma Informatic /ID# 279189
RECRUITING

Katy, Texas, 77494, United States
Cape Fear Arthritis Care /ID# 272076
NOT_YET_RECRUITING

Leland, North Carolina, 28451, United States
Care & Cure Clinic /ID# 281684
RECRUITING

Houston, Texas, 77909, United States

Contact Phone: •••-•••-••••
Care Clinic - Calgary /ID# 274405
RECRUITING

Calgary, Alberta, T2N 4L7, Canada
Centre Hospitalier Universite De Sherbrooke - Hotel-Dieu Hospital /ID# 273711
RECRUITING

Sherbrooke, Quebec, J1G 2E8, Canada
Centro Reumatologico De Caguas /ID# 277918
RECRUITING

Caguas, 00725, Puerto Rico
Centrum Kliniczno-Badawcze J.Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka /ID# 272966
RECRUITING

Elblag, Warmian-Masurian Voivodeship, 82-300, Poland
Centrum Medyczne Reuma Park /ID# 272968
RECRUITING

Warsaw, Masovian Voivodeship, 02-665, Poland
Centrum Nowoczesnych Terapii Dobry Lekarz sp.z.o.o. /ID# 281209
RECRUITING

Krakow, Lesser Poland Voivodeship, 31-011, Poland
Clinical Research Investigator Group /ID# 274821
RECRUITING

Bayamón, 00960, Puerto Rico
Clinical Research Of West Florida - Phase I Unit /ID# 272428
RECRUITING

Clearwater, Florida, 33765, United States
Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 272755
RECRUITING

Tampa, Florida, 33606, United States

Contact Phone: •••-•••-••••
Clinical Research Puerto Rico /ID# 281346
RECRUITING

San Juan, 00909-1738, Puerto Rico
Cohen Medical Centers /ID# 278341
RECRUITING

Thousand Oaks, California, 91360, United States
Complejo Hospitalario Universitario A Coruña /ID# 272609
RECRUITING

A Coruña, A Coruna, 15006, Spain
Complex Rendelo Med Zrt. /ID# 272859
RECRUITING

Székesfehérvár, Fejér, 8000, Hungary
Consorci Hospital General Universitario de Valencia /ID# 272615
RECRUITING

Valencia, 46014, Spain
DJL Clinical Research - Charlotte /ID# 272387
RECRUITING

Charlotte, North Carolina, 28211-1064, United States
DM Clinical Research - Tomball /ID# 272452
RECRUITING

Tomball, Texas, 77375, United States
DM Clinical Research -Tomball RCH /ID# 281787
RECRUITING

Tomball, Texas, 77377, United States
Deerbrook Medical Associates /ID# 273439
RECRUITING

Libertyville, Illinois, 60048, United States
Dr. Latha Naik Medical Professional Corporation /ID# 274403
RECRUITING

Saskatoon, Saskatchewan, S7H 0P4, Canada
Epic Medical Research /ID# 272656
RECRUITING

Red Oak, Texas, 75154, United States
Etyka Osrodek Badan Klinicznych /ID# 272974
RECRUITING

Olsztyn, Warmian-Masurian Voivodeship, 10-117, Poland
Finlay Medical Research - Greenacres /ID# 281654
RECRUITING

Greenacres City, Florida, 33467, United States
Fort Bend Rheumatology Associates /ID# 280761
RECRUITING

Sugar Land, Texas, 77479, United States
GCM Medical Group, PSC /ID# 273016
RECRUITING

San Juan, 00917, Puerto Rico
HMD Research LLC /ID# 272432
RECRUITING

Orlando, Florida, 32819, United States
Hanyang University Seoul Hospital /ID# 273625
RECRUITING

Seoul, Seoul Teugbyeolsi, 04763, South Korea
Highlands Advanced Rheumatology And Arthritis Center - Avon Park /ID# 272298
RECRUITING

Avon Park, Florida, 33825, United States
Hoskinson Health & Wellness Clinic /ID# 281689
NOT_YET_RECRUITING

Gillette, Wyoming, 82718, United States
Hospital General Universitario Gregorio Maranon /ID# 272616
RECRUITING

Madrid, 28007, Spain
Hospital Universitari Parc Tauli /ID# 272607
RECRUITING

Sabadell, Barcelona, 08208, Spain
Hospital Universitario Reina Sofia /ID# 272613
RECRUITING

Córdoba, 14004, Spain
Hospital Universitario de Valme /ID# 281266
RECRUITING

Seville, Sevilla, 41014, Spain
Hospital de Basurto /ID# 272610
RECRUITING

Bilbao, Vizcaya, 48013, Spain
Inland Rheumatology and Osteoporosis Medical Group /ID# 272449
RECRUITING

Upland, California, 91786, United States
Institute Of Rheumatology /ID# 280055
RECRUITING

Belgrade, Beograd, 11000, Serbia
Joint And Muscle Research Institute /ID# 277290
RECRUITING

Charlotte, North Carolina, 28204, United States
Krankenhaus Porz Am Rhein /ID# 272903
RECRUITING

Cologne, North Rhine-Westphalia, 51149, Germany
L.K.N. Arthrocentrum /ID# 271932
RECRUITING

Hlučín, Moravian-Silesian Region, 748 01, Czechia
LeJenue Research Associates /ID# 272269
NOT_YET_RECRUITING

Miami, Florida, 33126, United States
Life Clinical Trials - Colonial Drive - Margate /ID# 272589
RECRUITING

Margate, Florida, 33063, United States
Low Country Rheumatology /ID# 277607
RECRUITING

Summerville, South Carolina, 29486, United States
MEDICAL PLUS Research s.r.o /ID# 271926
RECRUITING

Uherské Hradiště, 686 01, Czechia
MEDMAN s.r.o. /ID# 278688
RECRUITING

Martin, Žilina Region, 036 01, Slovakia
Malopolskie Centrum Kliniczne /ID# 272965
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-149, Poland
Medicover Integrated Clinical Services - Bydgoszcz (SMO/Network/Consortium) /ID# 272975
RECRUITING

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-068, Poland
Mindful Medical Research /ID# 281521
RECRUITING

San Juan, 00918-3756, Puerto Rico

Contact Phone: •••-•••-••••
Mvz Rheuma /ID# 272795
RECRUITING

Hamburg, 20095, Germany
Neoclinical Research - Hialeah /ID# 272070
RECRUITING

Hialeah, Florida, 33016, United States
Newport Huntington Medical Group /ID# 272439
RECRUITING

Huntington Beach, California, 92648-5994, United States
Northwell Health Physician Partners Rheumatology At Great Neck /ID# 275621
RECRUITING

Great Neck, New York, 11021, United States
Northwestern Medicine - Northwestern Memorial Hospital /ID# 275422
RECRUITING

Chicago, Illinois, 60611, United States
PV Medical Services /ID# 271934
RECRUITING

Zlín, 760 01, Czechia
Paramount Medical Research and Consulting /ID# 272474
RECRUITING

Middleburg Heights, Ohio, 44130, United States
Private Practice - Dr. David S. Hallegua /ID# 277608
RECRUITING

Beverly Hills, California, 90211, United States
Private Practice - Dr. Laila A. Hassan /ID# 272297
RECRUITING

Houston, Texas, 77089, United States
Qualiclinic /ID# 281259
RECRUITING

Budapest, 1134, Hungary
Reuviva Research Center /ID# 277140
RECRUITING

Guaynabo, 00968-8050, Puerto Rico
Revita Reumatologiai Rendelo (Revita Kft.) /ID# 281247
RECRUITING

Budapest, 1027, Hungary
Rheumateam Lahn-Dill-Siegerland /ID# 274858
RECRUITING

Wetzlar, Hesse, 35578, Germany
SMG-SNU Boramae Medical Center /ID# 273627
RECRUITING

Seoul, Seoul Teugbyeolsi, 07061, South Korea
Sahni Rheumatology & Therapy /ID# 278352
RECRUITING

West Long Branch, New Jersey, 07764, United States
Santurce Clinical Trials and Infusion Center /ID# 277927
RECRUITING

San Juan, 00909, Puerto Rico

Contact Phone: •••-•••-••••
Semmelweis Egyetem Reumatológiai és Immunológiai Klinika /ID# 273212
RECRUITING

Budapest, 1023, Hungary
SoonChunHyang University Hospital Cheonan /ID# 277624
RECRUITING

Cheonan-si, Chungcheongnam-do, 31151, South Korea
South Florida Rheumatology /ID# 278339
RECRUITING

Hollywood, Florida, 33026, United States
Southwest Rheumatology Research /ID# 272268
RECRUITING

Mesquite, Texas, 75150, United States

Contact Phone: •••-•••-••••
Specijalna Bolnica za Reumatske bolesti Novi Sad /ID# 280057
RECRUITING

Novi Sad, Juznobacki Okrug, 21000, Serbia
Specijalna Bolnica za Reumatske bolesti Novi Sad /ID# 280058
RECRUITING

Novi Sad, Juznobacki Okrug, 21000, Serbia
Sun Valley Arthritis Center /ID# 278331
RECRUITING

Peoria, Arizona, 85381, United States
Swati Shah, MD Rheumatology /ID# 273624
RECRUITING

Jacksonville, Florida, 32257, United States
Szegedi Tudomanyegyetem /ID# 272865
RECRUITING

Szeged, Csongrád megye, 6720, Hungary
Szpital Uniwersytecki Nr 2 Im. Dr Jana Biziela W Bydgoszczy /ID# 281180
RECRUITING

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-168, Poland
Taoyuan General Hospital /ID# 280044
RECRUITING

Taoyuan City, 330, Taiwan
Tekton Research - Fort Collins - East Harmony Road /ID# 272472
RECRUITING

Fort Collins, Colorado, 80528, United States
Tekton Research - West Gate /ID# 272270
RECRUITING

Austin, Texas, 78745, United States
Texas Digestive Disease Consultants - Southlake /ID# 277652
NOT_YET_RECRUITING

Southlake, Texas, 76092, United States
Texas Rheumatology Research Institute Llc /Id# 278010
RECRUITING

Plano, Texas, 75024, United States
The Lundquist Institute /ID# 272481
RECRUITING

Torrance, California, 90502, United States
Trinity Universal Research Associates - Carrollton /ID# 272577
RECRUITING

Carrollton, Texas, 75007, United States
Universitaetsklinikum Bonn /ID# 272808
RECRUITING

Bonn, North Rhine-Westphalia, 53127, Germany
Vital-Medicina /ID# 272858
RECRUITING

Veszprém, Fejér, 8200, Hungary
Vitalia Research /ID# 272478
RECRUITING

Palm Beach Gardens, Florida, 33410, United States
West Tennessee Research Institute /ID# 272453
RECRUITING

Jackson, Tennessee, 38305, United States
Willow Rheumatology and Wellness /ID# 272691
RECRUITING

Willowbrook, Illinois, 60527, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Lutikizumab and ravagalimab (injectable drugs)

What this could lead to

If successful, these drugs could offer new treatment options for people with rheumatoid arthritis who haven't responded well to other therapies.

What could go wrong

This is an early-phase trial with a small number of participants. The drugs may not work better than placebo, and side effects are possible.

Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS