New drug combo aims to shrink ovarian tumors before surgery

NCT ID NCT06890338

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Nov 03, 2025

Summary

This study tests whether giving the targeted drug mirvetuximab soravtansine together with standard chemotherapy (carboplatin) before surgery can shrink advanced ovarian, fallopian tube, or peritoneal cancers that have a specific protein (FRα). About 140 adults with stage III or IV disease will receive the combination every 3 weeks for up to 9 cycles. The goal is to see how many tumors respond before surgery, while also monitoring side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Atrium Health Levine Cancer Institute /ID# 274557
RECRUITING

Charlotte, North Carolina, 28204, United States
Atrium Health Wake Forest Baptist Medical Center /ID# 276952
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Avera Cancer Institute - Sioux Falls /ID# 276226
RECRUITING

Sioux Falls, South Dakota, 57105, United States
Baptist Health Lexington /ID# 275218
RECRUITING

Lexington, Kentucky, 40503, United States
California Pacific Medical Center /ID# 275329
RECRUITING

San Francisco, California, 94109, United States
Carilion Roanoke Memorial Hospital /ID# 274684
RECRUITING

Roanoke, Virginia, 24014, United States
Carle Foundation Hospital /ID# 276470
RECRUITING

Urbana, Illinois, 61801, United States
Cleveland Clinic - Cleveland /ID# 276133
RECRUITING

Cleveland, Ohio, 44195, United States
Cleveland Clinic - Cleveland /ID# 278273
RECRUITING

Cleveland, Ohio, 44195, United States
Cleveland Clinic - Cleveland /ID# 278274
RECRUITING

Cleveland, Ohio, 44195, United States
Compass Oncology - West - Tigard /ID# 275101
RECRUITING

Tigard, Oregon, 97223, United States

Contact Phone: •••-•••-••••
Cox Medical Center South /ID# 274826
RECRUITING

Springfield, Missouri, 65807, United States
Danbury Hospital, Western Connecticut Health Network /ID# 274783
RECRUITING

Danbury, Connecticut, 06810, United States
Dartmouth-Hitchcock Medical Center /ID# 274676
RECRUITING

Lebanon, New Hampshire, 03756, United States
East Carolina University - Brody School of Medicine /ID# 275770
RECRUITING

Greenville, North Carolina, 27834, United States
Holy Cross Hospital /ID# 275872
RECRUITING

Silver Spring, Maryland, 20910, United States
Holy Name Medical Center /ID# 276240
RECRUITING

Teaneck, New Jersey, 07666, United States
Houston Methodist Hospital /ID# 274568
RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-••••
Imbert Cancer Center /ID# 275634
RECRUITING

Bay Shore, New York, 11706, United States
Indiana University Melvin and Bren Simon Cancer Center /ID# 275492
RECRUITING

Indianapolis, Indiana, 46202, United States
Inova Schar Cancer Institute - Fairfax - Innovation Park Drive /ID# 276456
RECRUITING

Fairfax, Virginia, 22031, United States
Jupiter Medical Center /ID# 276616
RECRUITING

Jupiter, Florida, 33458, United States
Kettering Medical Center /ID# 274365
RECRUITING

Kettering, Ohio, 45429, United States
Mercy Hospital St. Louis /ID# 275655
RECRUITING

St Louis, Missouri, 63141, United States
Metro Minnesota Community Oncology Research Consortium (MMCORC) /ID# 274780
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Mount Sinai Medical Center /ID# 274868
RECRUITING

Miami Beach, Florida, 33140, United States

Contact Phone: •••-•••-••••
Northwell Health Cancer Institute At Huntington /ID# 276814
RECRUITING

Greenlawn, New York, 11740, United States
Northwell Health Center for Advanced Medicine. /ID# 275641
RECRUITING

Lake Success, New York, 11042, United States
Northwell Health Queens Cancer Center /ID# 274850
RECRUITING

Rego Park, New York, 11374, United States
Norton Cancer Institute - St. Matthews /ID# 276173
RECRUITING

Louisville, Kentucky, 40207, United States
Norwalk Hospital /ID# 274561
RECRUITING

Norwalk, Connecticut, 06856, United States
OSF St. Francis Medical Center /ID# 274752
RECRUITING

Peoria, Illinois, 61637-0001, United States
Oncology Associates of Oregon, P.C. /ID# 275006
RECRUITING

Eugene, Oregon, 97401, United States
Optimum Clinical Research Group /ID# 274583
RECRUITING

Albuquerque, New Mexico, 87109, United States
Parkview Research Center /ID# 274338
RECRUITING

Fort Wayne, Indiana, 46845, United States
Providence Sacred Heart Medical Center & Children'S Hospital /ID# 274585
RECRUITING

Spokane, Washington, 99204, United States
Ridley Tree Cancer Center /ID# 275219
ACTIVE_NOT_RECRUITING

Santa Barbara, California, 93105, United States
Rush Md Anderson Cancer Center /ID# 274926
RECRUITING

Chicago, Illinois, 60607, United States
Rutgers Cancer Institute of New Jersey /ID# 274358
RECRUITING

New Brunswick, New Jersey, 08901, United States
Sanford Cancer Center /ID# 274901
RECRUITING

Sioux Falls, South Dakota, 57104, United States
Sanford Fargo Medical Center - Fargo /ID# 275489
RECRUITING

Fargo, North Dakota, 58102, United States
Scripps Md Anderson - Prebys Cancer Center /ID# 276891
RECRUITING

San Diego, California, 92103, United States
St. Lukes University Hospital /ID# 274362
RECRUITING

Bethlehem, Pennsylvania, 18015, United States
Texas Oncology - Austin Central /ID# 275046
RECRUITING

Austin, Texas, 78731, United States
Texas Oncology - Fort Worth Cancer Center /ID# 275043
RECRUITING

Fort Worth, Texas, 76104, United States
Texas Oncology - Northeast Texas /ID# 275057
RECRUITING

Tyler, Texas, 75702, United States
Texas Oncology - San Antonio Medical Center - Research Drive /ID# 275090
RECRUITING

San Antonio, Texas, 78240, United States
Texas Oncology - The Woodlands /ID# 275015
RECRUITING

The Woodlands, Texas, 77380, United States
The Center Of Hope /ID# 274313
RECRUITING

Reno, Nevada, 89511, United States
The Mark H Zangmeister Center /ID# 275106
RECRUITING

Columbus, Ohio, 43219, United States
Trials 365 /ID# 274310
RECRUITING

Shreveport, Louisiana, 71103, United States
UVA Health University Hospital /ID# 275309
RECRUITING

Charlottesville, Virginia, 22903, United States
University Medical Center New Orleans /ID# 274755
RECRUITING

New Orleans, Louisiana, 70112, United States
University Of Mississippi Medical Center /ID# 276342
RECRUITING

Jackson, Mississippi, 39216, United States
University of Alabama at Birmingham (UAB) Hospital /ID# 274793
RECRUITING

Birmingham, Alabama, 35294, United States
University of California Los Angeles Medical Center /ID# 274566
RECRUITING

Los Angeles, California, 90095, United States
University of Maryland, Baltimore /ID# 275308
RECRUITING

Baltimore, Maryland, 21201, United States
University of Minnesota - Minneapolis /ID# 275718
RECRUITING

Minneapolis, Minnesota, 55455-0341, United States
University of North Carolina Medical Center /ID# 275307
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Pennsylvania /ID# 275612
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Usa Mitchell Cancer Institute /ID# 276022
RECRUITING

Mobile, Alabama, 36604, United States
Virginia Oncology Associates- Norfolk (Brock) /ID# 275227
RECRUITING

Norfolk, Virginia, 23502-2800, United States
West Virginia University School of Medicine /ID# 274556
RECRUITING

Morgantown, West Virginia, 26506, United States
Women & Infants Hospital /ID# 274716
RECRUITING

Providence, Rhode Island, 02905, United States
Women'S Cancer Care /ID# 276469
RECRUITING

Covington, Louisiana, 70433, United States
Yale University School of Medicine /ID# 275794
RECRUITING

New Haven, Connecticut, 06510, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

mirvetuximab soravtansine (MIRV) combined with carboplatin

What this could lead to

If successful, this combination could shrink advanced ovarian tumors before surgery, potentially improving surgical outcomes and delaying disease progression.

What could go wrong

This is an early Phase 2 study with no control group, so results are preliminary. The treatment may cause side effects like fatigue, nausea, or infusion reactions, and may not work for everyone.

Conditions

The condition(s) this trial relates to.

Carcinoma, Ovarian Epithelial fallopian tube cancer fallopian tube neoplasm ovarian carcinoma ovarian serous adenocarcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPITHELIAL OVARIAN CANCER FALLOPIAN TUBE CANCER NEOADJUVANT PRIMARY PERITONEAL CANCER