Could removing just one lymph node stop melanoma from coming back?

NCT ID NCT05839912

First seen Nov 01, 2025 · Last updated Jun 17, 2026 · Updated 34 times

Summary

This study is for people with stage III melanoma that has spread to just one lymph node. Researchers want to see if removing only that cancerous node (instead of many nodes) can prevent the cancer from returning in the same area. The study will also track side effects like swelling and how the surgery affects daily life. About 66 adults will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Cancer Center at the University of Virginia

    RECRUITING

    Charlottesville, Virginia, 22908, United States

  • Duke University Health System

    RECRUITING

    Durham, North Carolina, 27710, United States

    Contact Email: •••••@•••••

  • Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • University of Maryland

    NOT_YET_RECRUITING

    Baltimore, Maryland, 21201, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of Pennsylvania

    NOT_YET_RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

Conditions

The condition(s) this trial relates to.

melanoma metastatic melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.