Ketamine showdown: which form works best for stubborn depression?
NCT ID NCT06278779
First seen Jun 25, 2026 · Last updated Jun 25, 2026 · Updated 1 time
Summary
This study compares two forms of ketamine—Spravato (a nasal spray) and standard racemic ketamine (given as an infusion)—in 162 adults with treatment-resistant depression. Participants will be randomly assigned to one treatment and will complete questionnaires about mood, side effects, and quality of life. The goal is to see which option is more effective and better tolerated.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Black Dog Institute
RECRUITINGRandwick, New South Wales, 2031, Australia
Contact
Contact Email: •••••@•••••
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Gold Coast University Hospital
RECRUITINGSouthport, Queensland, 4215, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Ramsay Clinic Albert Road
RECRUITINGMelbourne, Victoria, 3004, Australia
Contact
Contact Email: •••••@•••••
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Ramsay Clinic Lakeside
RECRUITINGWarners Bay, New South Wales, 2282, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Email: •••••@•••••
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Ramsay Clinic Northside
RECRUITINGSt Leonards, New South Wales, 2065, Australia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal Melbourne Hospital
RECRUITINGParkville, Victoria, 3052, Australia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal Prince Alfred Hospital
RECRUITINGCamperdown, New South Wales, 2050, Australia
Contact
Contact Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketamine (Spravato and racemic ketamine)
What this could lead to
If successful, this trial could show which form of ketamine works better for people with hard-to-treat depression, potentially improving treatment guidelines.
What could go wrong
This is a relatively small study (162 people) and results may not apply to everyone. Ketamine can cause side effects like dissociation and blood pressure changes, and long-term effects are still being studied.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.