Could taking drug holidays improve CLL treatment?

NCT ID NCT07014917

First seen Jan 11, 2026 · Last updated Jun 18, 2026 · Updated 24 times

Summary

This study tests whether taking the targeted drug venetoclax on an intermittent schedule (with breaks) works as well as taking it continuously, when combined with acalabrutinib, in people with previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. About 62 participants will be randomly assigned to one of the two schedules. The goal is to see if the intermittent approach can achieve similar remission rates while possibly reducing side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • University of Cincinnati

    RECRUITING

    Cincinnati, Ohio, 45219, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.