Which NSAID is best? large trial tests indomethacin vs diclofenac to prevent Post-ERCP pancreatitis
NCT ID NCT07071441
First seen Jan 06, 2026 · Last updated Jun 23, 2026 · Updated 36 times
Summary
This study compares two rectal non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and diclofenac, to see which one better prevents pancreatitis after an ERCP procedure. About 4050 adults aged 18-90 with an intact papilla will be randomly assigned to receive one of the drugs before the procedure. The goal is to find out if indomethacin is superior to diclofenac in reducing the risk of this common complication.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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986 Hospital of Xijing Hospital
RECRUITINGXi'an, Shaanxi, 710000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Affiliated Hangzhou First People's Hospital
NOT_YET_RECRUITINGHangzhou, Zhejiang, 310000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Gastroenterology, Hongai Hospital
RECRUITINGXiamen, Fujian, 361000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Eastern Hepatobiliary Surgery Hospital
RECRUITINGShanghai, Shanghai Municipality, 200000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Harbin Medical University Affiliated Fourth Hospital
RECRUITINGHarbin, Heilongjiang, 150000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Huaihe Hospital of Henan University
RECRUITINGKaifeng, Hennan, 475000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jilin Miniciple People'S Hospital
RECRUITINGJilin City, Jilin, 132000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Qinghai University Affiliated Hospital
RECRUITINGXining, Qinghai, 810000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Renmin hospital of Wuhan University
RECRUITINGWuhan, Hubei, 430000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Second Affiliated Hospital of Xi'an Jiaotong University
RECRUITINGXi'an, Shaanxi, 710000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shandong Provincial Third Hospital
NOT_YET_RECRUITINGJinan, Shandong, 250000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The 960th Hospital of the PLA
RECRUITINGJinan, Shandong, 250000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Affiliated Hospital of Chongqing Medical University
RECRUITINGChongqing, Chongqing Municipality, 404100, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Third Xiangya Hospital of Central South University
NOT_YET_RECRUITINGChangsha, Hunan, 410000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The first medical center, Chinese PLA General Hospital
RECRUITINGBeijing, Beijing Municipality, 100000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITINGWuhan, Hubei, 430000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Xijing Hospital of Digestive Diseases
RECRUITINGXi'an, Shaanxi, 710000, China
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RECRUITING
Harbin, Heilongjiang, 150000, China
Contact Phone: •••-•••-••••
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the First Affiliated Hospital, Zhejiang University School of Medicine
RECRUITINGHangzhou, Zhejiang, 310000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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the second Affiliated Hospital, Zhejiang University School of Medicine
NOT_YET_RECRUITINGHangzhou, Zhejiang, 310000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Indomethacin and diclofenac (non-steroidal anti-inflammatory drugs, given as rectal suppositories)
What this could lead to
If it works, this could show that indomethacin is better than diclofenac at preventing pancreatitis after ERCP, helping doctors choose the most effective preventive drug.
What could go wrong
This is a large trial, but it follows an earlier smaller study that was stopped early. The difference between the two drugs may still be small, and individual patient factors could affect results.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.