New drug combo aims to heal gut in Crohn's patients
NCT ID NCT06227910
First seen Jun 07, 2026
Summary
This study tests whether giving two drugs together (vedolizumab and upadacitinib) for 12 weeks works better than vedolizumab alone to reduce bowel inflammation and ulcers in adults with moderate to severe Crohn's disease. About 396 participants will receive the combo or a placebo combo, then all responders switch to vedolizumab alone for 40 more weeks. The goal is to see if the initial combo leads to better long-term control of the disease.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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A. Gemelli University Hospital, Catholic University of the Sacred Heart
NOT_YET_RECRUITINGRoma, 00168, Italy
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AO Ordine Mauriziano di Torino
NOT_YET_RECRUITINGTorino, 10122, Italy
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Aalborg Hospital
NOT_YET_RECRUITINGAalborg, 9000, Denmark
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Adelaide, Meath and National Children's Hospital
NOT_YET_RECRUITINGDublin, 24, Ireland
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Agaplesion Markus Krankenhaus
NOT_YET_RECRUITINGFrankfurt am Main, 60431, Germany
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Akershus University Hospital
NOT_YET_RECRUITINGLorenskog, 1478, Norway
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Amsterdam UMC Research BV
NOT_YET_RECRUITINGAmsterdam, 1105 AZ, Netherlands
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Azienda Ospedaliero Universitaria Federico II di Napoli
NOT_YET_RECRUITINGNaples, 80131, Italy
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Barrie GI Associates
RECRUITINGBarrie, Ontario, L4M 7G1, Canada
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Beaumont Hospital
NOT_YET_RECRUITINGDublin, D09 V2N0, Ireland
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CHU St Etienne Hopital Nord
NOT_YET_RECRUITINGSaint-Etienne, 42270, France
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CHU d'Amiens-Picardie - Hopital SUD
NOT_YET_RECRUITINGAmiens, 80054, France
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Central Hospital of Northern Pest - Military Hospital
NOT_YET_RECRUITINGBudapest, 1062, Hungary
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Centre Hospitalier Chretien MontLegia
NOT_YET_RECRUITINGLiège, 4000, Belgium
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Centre Hospitalier Regional Universitaire de Nancy, Hopital Brabois
NOT_YET_RECRUITINGVandœuvre-lès-Nancy, 54511, France
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Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital Rangueil
ACTIVE_NOT_RECRUITINGToulouse, 31059, France
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Centre Hospitalier Universitaire de Bordeaux - Hopital Haut-Leveque
ACTIVE_NOT_RECRUITINGPessac, 33600, France
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Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hopital Hotel Dieu
ACTIVE_NOT_RECRUITINGNantes, 44093, France
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Centre Hospitalier de l'Universite de Montreal
NOT_YET_RECRUITINGMontreal, Quebec, H2X 0A9, Canada
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Centro Hospitalar Universitario Lisboa Norte EPE
NOT_YET_RECRUITINGLisbon, 1649-028, Portugal
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Centro Hospitalar de Lisboa ocidental (CHLO), Hospital Egas Moniz
NOT_YET_RECRUITINGLisbon, 1349-019, Portugal
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Centro de Estudos Clinico do Interior Paulista - CECIP
NOT_YET_RECRUITINGJaú, São Paulo, 17201130, Brazil
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Chang Gung Memorial Foundation Linkou Chang Gung Memorial Hospital
NOT_YET_RECRUITINGTaoyuan City, 33305, Taiwan
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Changhua Christian Hospital
NOT_YET_RECRUITINGChanghua, 50006, Taiwan
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Chu - Hopital Nord
NOT_YET_RECRUITINGMarseille, 13015, France
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Chung Shan Medical University Hospital
NOT_YET_RECRUITINGTaichung, 40201, Taiwan
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Chung-Ang University Hospital
ACTIVE_NOT_RECRUITINGSeoul, 06973, South Korea
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Clinical Hospital Center Rijeka
ACTIVE_NOT_RECRUITINGRijeka, 51000, Croatia
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Columbia University Medical Center, New York-Presbyterian Hospital
NOT_YET_RECRUITINGNew York, New York, 10032, United States
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Complejo Hospitalario Universitario De Santiago De Compostela
NOT_YET_RECRUITINGSantiago de Compostela, 15706, Spain
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Complejo Hospitalario de Navarra (CHN)
ACTIVE_NOT_RECRUITINGPamplona, 31008, Spain
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Dalhousie University
NOT_YET_RECRUITINGHalifax, Nova Scotia, B3H 2Y9, Canada
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Danderyds Sjukhus AB
NOT_YET_RECRUITINGStockholm, 182 88, Sweden
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Elisabeth TweeSteden Ziekenhuis (ETZ)
NOT_YET_RECRUITINGTilburg, 5022 GC, Netherlands
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Erasmus Medisch Centrum
NOT_YET_RECRUITINGRotterdam, 3015 GD, Netherlands
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Ersta sjukhus
NOT_YET_RECRUITINGStockholm, 116 30, Sweden
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Faculdade de Medicina de Botucatu
NOT_YET_RECRUITINGBotucatu, São Paulo, 18618-970, Brazil
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Fakultni Nemocnice Hradec Kralove
NOT_YET_RECRUITINGHradec Králové, 500 05, Czechia
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Fondazione IRCSS Casa Sollievo Della Sofferenza
NOT_YET_RECRUITINGSan Giovanni Rotondo, 71013, Italy
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GI PROS, Inc.
ACTIVE_NOT_RECRUITINGNaples, Florida, 34102, United States
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Gastroenterology Associates
ACTIVE_NOT_RECRUITINGGreenville, South Carolina, 29607, United States
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H-T. Centrum Medyczne Sp. z o.o. Sp.k.
NOT_YET_RECRUITINGTychy, 43-100, Poland
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Haukeland Universitetssjukehus (Haukeland University Hospital)
NOT_YET_RECRUITINGBergen, N5021, Norway
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Hepato-Gastroenterologie HK, s.r.o.
NOT_YET_RECRUITINGHradec Králové, 500 12, Czechia
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Heritage Medical Research Clinic - University Of Calgary
ACTIVE_NOT_RECRUITINGCalgary, Alberta, T2N 4Z6, Canada
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Hopital Huriez - CHRU de Lille
NOT_YET_RECRUITINGLille, 59037, France
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Hopital Universitaire de Bruxelles/ Academisch Ziekenhuis Brussel
NOT_YET_RECRUITINGBrussels, Anderlecht, 1070, Belgium
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Hospital General Universitario Gregorio Maranon (HGUGM)
ACTIVE_NOT_RECRUITINGMadrid, 28007, Spain
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Hospital Universitari I Politecnic La Fe
NOT_YET_RECRUITINGValencia, 46026, Spain
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Hospital Universitari Son Espases
NOT_YET_RECRUITINGPalma, 07120, Spain
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Hospital Universitario Cajuru
NOT_YET_RECRUITINGCuritiba, Paraná, 80050-350, Brazil
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Hospital Universitario La Paz
ACTIVE_NOT_RECRUITINGMadrid, 28046, Spain
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Hospital das Clinicas of the University of Sao Paulo (Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC/FMUSP))
NOT_YET_RECRUITINGSão Paulo, 05403-010, Brazil
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Humanitas Clinical And Research Institute
NOT_YET_RECRUITINGRozzano, 20089, Italy
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Hvidovre Hospital Medicinsk Gastroenterologisk Afdeling
NOT_YET_RECRUITINGHvidovre, 2650, Denmark
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IBD Clinical and Research centre
NOT_YET_RECRUITINGPrague, 190 00, Czechia
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Imelda GI Clinical Research Center
ACTIVE_NOT_RECRUITINGBonheiden, 2820, Belgium
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Indiana University (IU) Health University Hospital
ACTIVE_NOT_RECRUITINGIndianapolis, Indiana, 46202, United States
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Inje University Haeundae Paik Hospital
RECRUITINGBusan, 48108, South Korea
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Johannes Kepler Universitat Linz (JKU)
NOT_YET_RECRUITINGLinz, 4021, Austria
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Karolinska Universitetssjukhuset - Hjartkliniken i Solna - Karolinska University Hospital
NOT_YET_RECRUITINGStockholm, 171 76, Sweden
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Keck Medicine Of USC - USC Healthcare Center 1
NOT_YET_RECRUITINGLos Angeles, California, 90033, United States
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Krankenhaus Waldfriede e.V.
NOT_YET_RECRUITINGBerlin, 14163, Germany
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Krankenhaus der Barmherzigen Brueder Wien
NOT_YET_RECRUITINGVienna, 1020, Austria
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Kyung Hee University Hospital
RECRUITINGSeoul, 02447, South Korea
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Landeskrankenhaus Salzburg, Innere Medizin I, Labor im Erdgeschoss
NOT_YET_RECRUITINGSalzburg, 5020, Austria
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Lenox Hill Hospital Northwell Health
ACTIVE_NOT_RECRUITINGNew York, New York, 10075, United States
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McMaster University - Farncombe Family Digestive Health Research Institute (FFDHRI)
ACTIVE_NOT_RECRUITINGHamilton, Ontario, L8S 4K1, Canada
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Medical College of Wisconsin Cancer Center - Froedtert Hospital
NOT_YET_RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Medical University Innsbruck
NOT_YET_RECRUITINGInnsbruck, Tyrol, 6020, Austria
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Medizinische Universitaet Wien - Allgemeines Krankenhaus der Stadt Wien (AKH) - Universitaetsklinik fuer Innere Medizin III
NOT_YET_RECRUITINGVienna, State of Vienna, 1090, Austria
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Meir Medical Center
NOT_YET_RECRUITINGKfar Saba, 44281, Israel
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Metaxa Cancer Hospital
NOT_YET_RECRUITINGPiraeus, Attica, 185 37, Greece
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Mount Sinai Hospital - The Susan and Leonard Feinstein Inflammatory Bowel Disease (IBD) Clinical Center
ACTIVE_NOT_RECRUITINGNew York, New York, 10029-5204, United States
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National Cheng Kung University Hospital
NOT_YET_RECRUITINGTainan, 70403, Taiwan
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National Defense Medical Center (NDMC) (Tri-Service General Hospital (TSGH)) - Neihu
NOT_YET_RECRUITINGTaipei, 11490, Taiwan
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Nemocnice Ceske Budejovice, a.s.
NOT_YET_RECRUITINGČeské Budějovice, 370 01, Czechia
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Oddzial Kliniczny Gastroenterologii Ogolnej i Onkologicznej SPZOZ Uniwersytecki Szpital Kliniczny Nr 1 im. Barlickiego Uniwersytetu Medycznego w Lodzi
NOT_YET_RECRUITINGLodz, 90-153, Poland
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Orlando Health Ambulatory Care Center
ACTIVE_NOT_RECRUITINGOrlando, Florida, 32806, United States
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Oslo Universitetssykehus HF, Ulleval
NOT_YET_RECRUITINGOslo, 0424, Norway
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Ospedale San Raffaele (HSR) Instituto Scientifico Universitario San Raffaele
NOT_YET_RECRUITINGMilan, 20132, Italy
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Panstwowy Instytut Medyczny MSWiA
NOT_YET_RECRUITINGWarsaw, 02-507, Poland
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Peak Gastroenterology Associates
RECRUITINGColorado Springs, Colorado, 80907, United States
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Pesquisare Saude
NOT_YET_RECRUITINGSanto André, São Paulo, 9080110, Brazil
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Poliklinika Borzan d.o.o.
NOT_YET_RECRUITINGOsijek, 31000, Croatia
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Queen Elizabeth University Hospital - NHS Greater Glasgow & Clyde - South Glasgow University Hospital Division
NOT_YET_RECRUITINGGlasgow, Scotland, G51 4TF, United Kingdom
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Rabin Medical Center - Beilinson Campus (Beilinson and Hasharon Hospital)
NOT_YET_RECRUITINGPetah Tikva, 49100, Israel
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Radboud University Medical Center
NOT_YET_RECRUITINGNijmegen, 6525 GA, Netherlands
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Rambam Health Care Campus (RHCC)
NOT_YET_RECRUITINGHaifa, 3109601, Israel
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Rapid City Medical Center
ACTIVE_NOT_RECRUITINGRapid City, South Dakota, 57701, United States
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Samodzielny Publiczny Szpital Kliniczny Im. H. Swiecickiego Um
NOT_YET_RECRUITINGPoznan, 60-354, Poland
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Semmelweis Egyetem
NOT_YET_RECRUITINGBudapest, 1082, Hungary
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Severance Hospital, Yonsei University Health System
ACTIVE_NOT_RECRUITINGSeoul, 03722, South Korea
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Soroka Medical Center
NOT_YET_RECRUITINGBeersheba, 8410101, Israel
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Southern Star Research Institute, LLC
RECRUITINGSan Antonio, Texas, 78229, United States
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St Thomas' Hospital - Guy's & St Thomas' NHS Foundation Trust
NOT_YET_RECRUITINGLondon, England, SE1 7EH, United Kingdom
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St. Marien- und St. Annastiftskrankenhaus
NOT_YET_RECRUITINGLudwigshafen, 67065, Germany
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Studiengesellschaft BSF
NOT_YET_RECRUITINGHalle, 06108, Germany
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Swedish Cancer Institute
NOT_YET_RECRUITINGSeattle, Washington, 98104, United States
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Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Szent-Gyorgyi Albert Klinikai Kozpont, I.Sz. Belogyaszati Klinika
NOT_YET_RECRUITINGSzeged, 6720, Hungary
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Taichung Veterans General Hospital
NOT_YET_RECRUITINGTaichung, 40705, Taiwan
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Taunton Surgical Centre-Oshawa Clinic
RECRUITINGOshawa, Ontario, L1J 0C7, Canada
Contact
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The Catholic University Of Korea, St. Vincent's Hospital
ACTIVE_NOT_RECRUITINGSuwon, 16247, South Korea
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The Catholic University of Korea, Daejeon St.Mary's Hospital
ACTIVE_NOT_RECRUITINGDaejeon, 34943, South Korea
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The Catholic University of Korea, Seoul St. Mary's Hospital
ACTIVE_NOT_RECRUITINGSeoul, 06591, South Korea
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The Royal London Hospital - Barts Health NHS Trust
NOT_YET_RECRUITINGLondon, Greater London, E1 1BB, United Kingdom
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The Tel Aviv Sourasky Medical Center
NOT_YET_RECRUITINGTel Aviv, 6423906, Israel
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Toronto Digestive Disease Associates
NOT_YET_RECRUITINGVaughan, Ontario, L4L 4Y7, Canada
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Toronto Immune and Digestive Health Institute (TIDHI)
RECRUITINGToronto, Ontario, M6A 3B4, Canada
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Tyler Research Institute, LLC
RECRUITINGTyler, Texas, 75701, United States
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UCSD Medical Center
NOT_YET_RECRUITINGLa Jolla, California, 92037, United States
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USF Health Morsani Center for Advanced Healthcare
ACTIVE_NOT_RECRUITINGTampa, Florida, 33612, United States
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Unidade Local de Saude Coimbra
NOT_YET_RECRUITINGCoimbra, 3000-075, Portugal
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Unidade de Pesquisa Clinica UPC Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo
NOT_YET_RECRUITINGSão Paulo, 1405-1243, Brazil
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Universidade Federal do Rio de Janeiro (UFRJ)-Hospital Universitario Clementino Fraga Filho (HUCFF)
NOT_YET_RECRUITINGRio de Janeiro, 21941-617, Brazil
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Universitaetsklinikum Jena
NOT_YET_RECRUITINGJena, 07747, Germany
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Universitaetsklinikum Mannheim (Umm) - Ii Medizinische Klinik
NOT_YET_RECRUITINGMannheim, 68167, Germany
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Universitaetsklinikum Schleswig-Holstein, UKSH-Campus Kiel
NOT_YET_RECRUITINGKiel, 24105, Germany
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Universitair Ziekenhuis Gent
NOT_YET_RECRUITINGGhent, 9000, Belgium
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Universitatsspital Zurich
NOT_YET_RECRUITINGZurich, 8091, Switzerland
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitetssjukhuset i Linkoping, Endokrin- och magtarmmedicinska Kliniken (EM-Kliniken)
NOT_YET_RECRUITINGLinköping, Sweden
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Clinical Centre - Ljubljana
NOT_YET_RECRUITINGLjubljana, 1000, Slovenia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University College Dublin (UCD) - St. Vincent's University Hospital (SVUH)
NOT_YET_RECRUITINGDublin, D04 T6F4, Ireland
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital Basel
NOT_YET_RECRUITINGBasel, 4031, Switzerland
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital Bern (Inselspital)
NOT_YET_RECRUITINGBern, 3010, Switzerland
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University Hospital Centre Sestre Milosrdnice
NOT_YET_RECRUITINGZagreb, 10000, Croatia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University Hospital of Heraklion
NOT_YET_RECRUITINGHeraklion, Crete, 71110, Greece
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University Hospitals Leuven
NOT_YET_RECRUITINGLeuven, 3000, Belgium
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Athens School of Medicine, Alexandra General Hospital
NOT_YET_RECRUITINGAthens, Attica, 11528, Greece
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kentucky
ACTIVE_NOT_RECRUITINGLexington, Kentucky, 40536, United States
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University of Manitoba-Winnipeg Regional Health Authority-Health Sciences Centre
NOT_YET_RECRUITINGWinnipeg, Manitoba, R3A 1R9, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Washington Medical Center - Montlake
NOT_YET_RECRUITINGSeattle, Washington, 98195, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vestre Viken HF - Baerum Sykehus
NOT_YET_RECRUITINGDrammen, Gjettum, 1309, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Virginia Mason Medical Center
ACTIVE_NOT_RECRUITINGSeattle, Washington, 98101, United States
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WIP Warsaw IBD Point Profesor Kierkus
NOT_YET_RECRUITINGWarsaw, 05-401, Poland
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Western General Hospital
NOT_YET_RECRUITINGEdinburgh, Lothian, EH4 2XU, United Kingdom
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Yeungnam University Medical Center
ACTIVE_NOT_RECRUITINGDaegu, 42415, South Korea
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Zentrum fur Gastroenterologie
NOT_YET_RECRUITINGZurich, 8048, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.