NIH launches study to uncover clues in mood disorder treatments

NCT ID NCT06462196

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 500 adults already receiving care for depression, bipolar disorder, or suicide risk at the NIH. Researchers will conduct weekly interviews and optional tests like blood draws and brain scans to track symptoms and treatment responses. The goal is to better understand how these disorders affect the body and find ways to predict which medications work best, especially for suicidal thoughts.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this study could help doctors predict which medications might reduce suicidal thoughts, improving personalized treatment for mood disorders.

What could go wrong

This is an observational study, not a treatment trial. It may not lead to immediate changes in care, and results depend on participant cooperation and existing treatments.

Conditions

The condition(s) this trial relates to.

Behavioral Symptoms bipolar depression bipolar disorder Depression depressive disorder Depressive Disorder, Treatment-Resistant major depressive disorder Self-Injurious Behavior Suicide

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.