Tailored diet app beats One-Size-Fits-All advice in heart health showdown
NCT ID NCT05273268
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether personalized nutrition advice, delivered through a smartphone app, could improve heart health markers like blood fats and weight better than standard USDA guidelines. 347 adults aged 40-70 with larger waistlines and low fruit/vegetable intake took part. The personalized plan used data on diet, lifestyle, and gut bacteria to give individual recommendations.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- personalized nutrition advice delivered through a mobile app
- What this could lead to
- If it works, this could point toward a more effective way to manage heart disease risk through tailored diet plans.
- What could go wrong
- This is a completed study, but the results are not yet widely confirmed. Personalized advice may not work for everyone, and the study only included people with specific waist sizes and low fruit/vegetable intake.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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347 people
The number who actually took part.
- Started
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Apr 2022
- Finished
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Sep 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 40-70 years * Any sex * Waist circumference greater than ethnic- and sex-specific 25th percentile values: Male * Hispanic \> 96.3cm * Asian \> 87.3cm * Black \> 92.7cm * White \> 96.9cm Female * Hispanic \> 90.7cm * Asian \> 80.9cm * Black \> 92.9cm * White \> 88.3cm * Fruit and vegetable intake below 450g/day (equivalent to 3 cups/day) * Willing to comply with study protocol * Live in the continental US, Hawaii or Alaska, and not in New York State (due to governmental regulations pertaining to dried blood spot testing). * Do not meet any of the exclusion criteria Exclusion Criteria: * Have taken part in the ZOE product or any PREDICT study beforehand. * Are unable to read and write in English, as the ZOE app is only available in English. * Do not complete the first Quest visit successfully * Have an iOS/Android device not compatible with app * Use medications affecting lipids (lipid lowering drugs e.g statins, anti-diabetic medications, e.g metformin and insulin), supplements including fish oil (unless willing to safely come off these for 4 weeks before the start of the study, and for the duration of study); * Have ongoing inflammatory disease e.g rheumatoid arthritis, systemic lupus erythematosus, polymyalgia and other connective tissue diseases. * Have had cancer in the last three years, excluding skin cancer. * Have chronic gastrointestinal disorders including inflammatory bowel disease (IBD) or Celiac disease (gluten allergy), but not including irritable bowel syndrome (IBS). * Are taking the following daily medications: immunosuppressants, corticosteroids, antibiotics in the last three months, not including inhalers. * Are users of prescription proton pump inhibitors (PPIs) (such as omeprazole and pantoprazol), unless they are able to stop two weeks before the start of the study and remain off them for the entire duration of the study (provided their treating physician deems it safe for them to do so). * Are currently suffering from acute clinically diagnosed depression or anxiety disorder. * Have had a heart attack (myocardial infarction) or stroke in the last 6 months. * Are pregnant or planning pregnancy in next 12 months, or are breastfeeding * Are vegan, have an eating disorder or unwilling to take foods that are part of the study. * Have an allergy to adhesives which would prevent proper attachment of the continuous glucose monitor.
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ZOE Ltd
Boston, Massachusetts, 02111, United States