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Tailored diet app beats One-Size-Fits-All advice in heart health showdown

NCT ID NCT05273268

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether personalized nutrition advice, delivered through a smartphone app, could improve heart health markers like blood fats and weight better than standard USDA guidelines. 347 adults aged 40-70 with larger waistlines and low fruit/vegetable intake took part. The personalized plan used data on diet, lifestyle, and gut bacteria to give individual recommendations.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
personalized nutrition advice delivered through a mobile app
What this could lead to
If it works, this could point toward a more effective way to manage heart disease risk through tailored diet plans.
What could go wrong
This is a completed study, but the results are not yet widely confirmed. Personalized advice may not work for everyone, and the study only included people with specific waist sizes and low fruit/vegetable intake.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

347 people

The number who actually took part.

Started

Apr 2022

Finished

Sep 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 40-70 years * Any sex * Waist circumference greater than ethnic- and sex-specific 25th percentile values: Male * Hispanic \> 96.3cm * Asian \> 87.3cm * Black \> 92.7cm * White \> 96.9cm Female * Hispanic \> 90.7cm * Asian \> 80.9cm * Black \> 92.9cm * White \> 88.3cm * Fruit and vegetable intake below 450g/day (equivalent to 3 cups/day) * Willing to comply with study protocol * Live in the continental US, Hawaii or Alaska, and not in New York State (due to governmental regulations pertaining to dried blood spot testing). * Do not meet any of the exclusion criteria Exclusion Criteria: * Have taken part in the ZOE product or any PREDICT study beforehand. * Are unable to read and write in English, as the ZOE app is only available in English. * Do not complete the first Quest visit successfully * Have an iOS/Android device not compatible with app * Use medications affecting lipids (lipid lowering drugs e.g statins, anti-diabetic medications, e.g metformin and insulin), supplements including fish oil (unless willing to safely come off these for 4 weeks before the start of the study, and for the duration of study); * Have ongoing inflammatory disease e.g rheumatoid arthritis, systemic lupus erythematosus, polymyalgia and other connective tissue diseases. * Have had cancer in the last three years, excluding skin cancer. * Have chronic gastrointestinal disorders including inflammatory bowel disease (IBD) or Celiac disease (gluten allergy), but not including irritable bowel syndrome (IBS). * Are taking the following daily medications: immunosuppressants, corticosteroids, antibiotics in the last three months, not including inhalers. * Are users of prescription proton pump inhibitors (PPIs) (such as omeprazole and pantoprazol), unless they are able to stop two weeks before the start of the study and remain off them for the entire duration of the study (provided their treating physician deems it safe for them to do so). * Are currently suffering from acute clinically diagnosed depression or anxiety disorder. * Have had a heart attack (myocardial infarction) or stroke in the last 6 months. * Are pregnant or planning pregnancy in next 12 months, or are breastfeeding * Are vegan, have an eating disorder or unwilling to take foods that are part of the study. * Have an allergy to adhesives which would prevent proper attachment of the continuous glucose monitor.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • ZOE Ltd

    Boston, Massachusetts, 02111, United States