New hope for lymphoma patients: targeted drug combo aims to delay cancer return

NCT ID NCT06717347

Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 18, 2026 · Updated 20 times

Summary

This study tests whether adding the targeted drug zilovertamab vedotin to standard chemotherapy (R-CHP) helps people with untreated diffuse large B-cell lymphoma live longer without their cancer growing or spreading, compared to the current standard treatment (R-CHOP). About 1,046 participants will be randomly assigned to one of the two treatment groups. The main goal is to see if the new combination improves progression-free survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,046 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Mar 2032

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Has histologically confirmed diagnosis of diffuse large B-cell lymphoma (DLBCL), by prior biopsy, based on local testing according to the WHO classification of neoplasms of the hematopoietic and lymphoid tissues * Has positron emission tomography (PET) positive disease at screening, defined as 4 to 5 on the Lugano 5-point scale * Has received no prior treatment for their DLBCL * Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 assessed within 7 days before randomization * Has an ejection fraction ≥45% as determined by either echocardiogram (ECHO) or multigated acquisition (MUGA) * Human immunodeficiency virus (HIV) infected participants must have well controlled HIV on antiretroviral therapy (ART) * Who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy and have undetectable HBV viral load prior to randomization * Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at screening Exclusion Criteria: * Has a history of transformation of indolent disease to DLBCL * Has received a diagnosis of primary mediastinal B-cell lymphoma (PMBCL) or Grey zone lymphoma * Has Ann Arbor Stage I DLBCL * Has clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (\<6 months prior to enrollment), myocardial infarction (\<6 months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association Classification Class ≥II), or serious cardiac arrhythmia requiring medication * Has clinically significant pericardial or pleural effusion * Has ongoing Grade \>1 peripheral neuropathy * Has a demyelinating form of Charcot-Marie-Tooth disease * HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease * Has ongoing corticosteroid therapy * Has received a live or live-attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines is allowed * Known additional malignancy that is progressing or has required active treatment within the past 2 years * Known active central nervous system (CNS) lymphoma * Has active autoimmune disease that has required systemic treatment in the past 2 years * Has active infection requiring systemic therapy * Has concurrent active HBV (defined as HBsAg positive and detectable HBV DNA) and HCV (defined as anti-HCV antibody positive and detectable HCV ribonucleic acid (RNA)) infection * Has history of allogeneic tissue/solid organ transplant

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diffuse large B-cell lymphoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

The study's own enquiry address

This study publishes an address for enquiries. See it below .
The places running it

255 sites in 35 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

1st Affil Hosp of Med College of Xi'an Jiaotong University ( Site 3107)
RECRUITING

Xi’an, Shanxi, 710061, China
AOU delle Marche Ospedali Riuniti di Ancona ( Site 2011)
RECRUITING

Ancona, 60126, Italy
ASBL CHU Helora - Hôpital de Mons - Site Kennedy ( Site 1103)
RECRUITING

Mons, Hainaut, 7000, Belgium
AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 1102)
RECRUITING

Mechelen, Antwerpen, 2800, Belgium
Aalborg University Hospital ( Site 1302)
RECRUITING

Aalborg, North Denmark, 9000, Denmark
Affiliated Cancer Hospital of Guangxi Medical University ( Site 3123)
RECRUITING

Nanning, Guangxi, 530021, China
Affiliated Hospital of Nantong University ( Site 3117)
RECRUITING

Nantong, Jiangsu, 226001, China
Albert Schweitzer Ziekenhuis ( Site 2103)
RECRUITING

Dordrecht, South Holland, 3318 AT, Netherlands
American Oncology Partners, P.A. ( Site 0185)
RECRUITING

Bethesda, Maryland, 20817, United States
Anhui Provincial Cancer Hospital ( Site 3124)
RECRUITING

Hefei, Anhui, 230031, China
Ankara University Faculty of Medicine ( Site 2801)
RECRUITING

Ankara, 06620, Turkey (Türkiye)
Antalya Egitim ve Arastirma Hastanesi ( Site 2805)
COMPLETED

Antalya, 7100, Turkey (Türkiye)
Asan Medical Center ( Site 3803)
RECRUITING

Seoul, 05505, South Korea
Attikon University General Hospital of Athens ( Site 1604)
RECRUITING

Athens, Attica, 124 62, Greece
Auxilio Mutuo Cancer Center ( Site 1001)
RECRUITING

San Juan, 00918, Puerto Rico
Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO ( Site 2005)
RECRUITING

Palermo, Sicily, 90146, Italy
Azienda Ospedaliera Spedali Civili di Brescia-Hemathology ( Site 2001)
RECRUITING

Brescia, 25123, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità ( Site 2004)
RECRUITING

Novara, 28100, Italy
BRCR Global Puerto Rico - Caribbean Cancer Care ( Site 1003)
RECRUITING

Yauco, 00698, Puerto Rico
Banner MD Anderson Cancer Center ( Site 0165)
RECRUITING

Gilbert, Arizona, 85234, United States
Banner MD Anderson Cancer Center - University Medical Center Phoenix ( Site 0167)
RECRUITING

Phoenix, Arizona, 85006, United States
Baskent Universitesi Adana Dr. Turgut Noyan UAM ( Site 2809)
COMPLETED

Adana, 01120, Turkey (Türkiye)
Beijing Cancer Hospital ( Site 3101)
RECRUITING

Beijing, Beijing Municipality, 100142, China
Biocenter ( Site 0510)
RECRUITING

Concepción, Biobio, 4070196, Chile
Bioresearch Partner ( Site 0157)
RECRUITING

Hialeah, Florida, 33013, United States
Blue Ridge Cancer Care ( Site 0132)
RECRUITING

Roanoke, Virginia, 24014, United States
Bradfordhill ( Site 0502)
RECRUITING

Santiago, Region M. de Santiago, 8420383, Chile
C.I.C.E. 9 de Julio ( Site 0305)
COMPLETED

San Miguel de Tucumán, Tucumán Province, T4000IKO, Argentina
CELAN,S.A ( Site 0702)
RECRUITING

Guatemala City, 01010, Guatemala
CEONC ( Site 0412)
RECRUITING

Cascavel, Paraná, 85803-760, Brazil
CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina ( Site 0403)
RECRUITING

Florianópolis, Santa Catarina, 88020-210, Brazil
CHD Vendee ( Site 1502)
RECRUITING

La Roche-sur-Yon, Vendee, 85000, France
CHRISTUS St. Frances Cabrini Hospital Center for Cancer Care ( Site 0184)
RECRUITING

Alexandria, Louisiana, 71301, United States
CHU Dijon Bourgogne ( Site 1516)
RECRUITING

Dijon, Cote-d Or, 21000, France
CHU GRENOBLE ALPES ( Site 1518)
RECRUITING

La Tronche, Isere, 38700, France
CIMAB SA de CV ( Site 0807)
COMPLETED

Torreón, Coahuila, 27000, Mexico
Cancer Blood and Specialty Clinic ( Site 0109)
RECRUITING

Los Alamitos, California, 90720, United States
Cancer Care Specialists ( Site 9582)
RECRUITING

Reno, Nevada, 89511, United States
Cancer Care Specialists of Illinois ( Site 0152)
RECRUITING

O'Fallon, Illinois, 62269, United States
Cantonal Hospital St.Gallen-Oncology & Hematology ( Site 2702)
RECRUITING

Sankt Gallen, Canton of St. Gallen, 9000, Switzerland
Carmel Hospital ( Site 1903)
RECRUITING

Haifa, 3436212, Israel
Cedars-Sinai Medical Center ( Site 0115)
RECRUITING

Los Angeles, California, 90048, United States
Cen Integral Onco Gastro y Hemato Onco Guatemala S.A. ( Site 0703)
RECRUITING

Guatemala City, 01010, Guatemala
Center for Oncology and Blood Disorders ( Site 0153)
COMPLETED

Houston, Texas, 77030, United States
Centre Antoine-Lacassagne ( Site 1514)
RECRUITING

Nice, Alpes-Maritimes, 06189, France
Centre Henri Becquerel ( Site 1517)
RECRUITING

Rouen, Seine-Maritime, 76038, France
Centre Hospitalier Régional Metz Thionville - Hôpital de Mercy ( Site 1515)
RECRUITING

Metz, Moselle, 57085, France
Centre Hospitalier Universitaire Estaing ( Site 1508)
RECRUITING

Clermont-Ferrand, Puy-de-Dome, 63100, France
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1512)
RECRUITING

Limoges, Limousin, 87042, France
Centre Hospitalier d'Avignon ( Site 1505)
RECRUITING

Avignon, Vaucluse, 84000, France
Centre Hospitalier de Dunkerque ( Site 1513)
RECRUITING

Dunkirk, Nord, 59385, France
Centre Hospitalier de la Cote Basque ( Site 1509)
RECRUITING

Bayonne, Pyrenees-Atlantiques, 64100, France
Centro de Estudios Clínicos SAGA ( Site 0508)
RECRUITING

Santiago, Region M. de Santiago, 7500653, Chile
Centro de Infusion Superare ( Site 0804)
RECRUITING

Mexico City, Mexico City, 03104, Mexico
Centro de Investigacion Clinica Chapultepec ( Site 0803)
RECRUITING

Morelia, Michoacán, 58260, Mexico
Centro de Investigacion Clinica de Oaxaca ( Site 0805)
RECRUITING

Oaxaca City, 68020, Mexico
Centro de Investigaciones ( Site 0511)
RECRUITING

Viña del Mar, Valparaiso, 2540488, Chile
Centrul de Diagnostic si Tratament Oncologic Brasov ( Site 2402)
RECRUITING

Brasov, 500052, Romania
Chang Gung Memorial Hospital - Linkou Branch ( Site 3903)
RECRUITING

Taoyuan City, Taoyuan, 333, Taiwan
Chang Gung Memorial Hospital at Kaohsiung ( Site 3905)
RECRUITING

Kaohsiung City, 83301, Taiwan
Chiba Cancer Center ( Site 3314)
RECRUITING

Chiba, 260-8717, Japan
Chongqing Cancer Hospital ( Site 3113)
RECRUITING

Chongqing, Chongqing Municipality, 400030, China
Chulalongkorn University ( Site 4003)
RECRUITING

Pathumwan, Bangkok, 10330, Thailand
Chungnam National University Hospital ( Site 3801)
RECRUITING

Daejeon, Taejon-Kwangyokshi, 35015, South Korea
Circuit Clinical - SSM Health Cancer Care DePaul ( Site 0166)
RECRUITING

Bridgeton, Missouri, 63044, United States
Clermont Oncology Center ( Site 0182)
RECRUITING

Clermont, Florida, 34711, United States
Clinica Advanze ( Site 0411)
RECRUITING

São Carlos, São Paulo, 13561-130, Brazil
Clinica Adventista Belgrano ( Site 0309)
RECRUITING

Caba., Buenos Aires, C1430EGF, Argentina
Clinica EL Castaño ( Site 0312)
COMPLETED

San Juan, J5400ARW, Argentina
Clinica Inmunocel ( Site 0503)
RECRUITING

Santiago, Region M. de Santiago, 7580206, Chile
Clínica RedSalud Vitacura ( Site 0512)
COMPLETED

Santiago, Region M. de Santiago, 7650018, Chile
Clínica San Felipe ( Site 0906)
RECRUITING

Lima, 15072, Peru
Clínicas AUNA Sede Chiclayo ( Site 0904)
RECRUITING

Chiclayo, Lambayeque, 14001, Peru
Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council" ( Site 2906)
RECRUITING

Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76008, Ukraine
Comprehensive Cancer Centers of Nevada ( Site 0113)
RECRUITING

Las Vegas, Nevada, 89169, United States
Corewell Health ( Site 0130)
RECRUITING

Grand Rapids, Michigan, 49503, United States
Cotton O'Neil Cancer Center ( Site 0108)
RECRUITING

Topeka, Kansas, 66606, United States
Cross Cancer Institute ( Site 0205)
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Debreceni Egyetem Klinikai Kozpont ( Site 1702)
RECRUITING

Debrecen, Hajdú-Bihar, 4032, Hungary
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi ( Site 2803)
RECRUITING

Ankara, 06200, Turkey (Türkiye)
East Carolina University ( Site 0159)
RECRUITING

Greenville, North Carolina, 27834, United States
Edward Cancer Center ( Site 0197)
RECRUITING

Naperville, Illinois, 60540, United States
Evangelismos General Hospital of Athens ( Site 1602)
RECRUITING

Athens, Attica, 106 76, Greece
F. F. R. M. São Jose do Rio Preto ( Site 0404)
RECRUITING

SJRP, São Paulo, 15090-000, Brazil
FALP ( Site 0501)
RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile
Faculty of Medicine Siriraj Hospital ( Site 4001)
COMPLETED

Bangkoknoi, Bangkok, 10700, Thailand
Fondazione IRCCS San Gerardo dei Tintori ( Site 2008)
RECRUITING

Monza, Lombardy, 20900, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 2003)
RECRUITING

Roma, 00168, Italy
Fort Wayne Medical Oncology and Hematology ( Site 0149)
RECRUITING

Fort Wayne, Indiana, 46804, United States
Fudan University Shanghai Cancer Center ( Site 3115)
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Fujian Provincial Cancer Hospital. ( Site 3119)
RECRUITING

Fuzhou, Fujian, 350014, China
Fundacion Estudios Clinicos ( Site 0311)
RECRUITING

Rosario, Santa Fe Province, S2000CEJ, Argentina
Fundación Valle del Lili ( Site 0602)
RECRUITING

Cali, Valle del Cauca Department, 760032, Colombia
General Hospital of Athens "Laiko"-Hematology Department ( Site 1603)
RECRUITING

Athens, Attica, 115 26, Greece
Grampians Health ( Site 3003)
RECRUITING

Ballarat, Victoria, 3350, Australia
Groote Schuur Hospital ( Site 2504)
RECRUITING

Cape Town, Western Cape, 7925, South Africa
Grupo Ollin Care ( Site 0806)
COMPLETED

Pachuca, Hidalgo, 42000, Mexico
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi ( Site 2804)
RECRUITING

Istanbul, 34722, Turkey (Türkiye)
H. Insular de Gran Canaria ( Site 2606)
RECRUITING

Las Palmas de Gran Canaria, Las Palmas, 35016, Spain
HIA Sainte Anne ( Site 1506)
RECRUITING

Toulon, Var, 83800, France
HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 2614)
RECRUITING

Madrid, 28007, Spain
Hacettepe Universite Hastaneleri ( Site 2810)
RECRUITING

Ankara, 06230, Turkey (Türkiye)
Hadassah Medical Center ( Site 1901)
RECRUITING

Jerusalem, 9112001, Israel
Haemalife ( Site 2501)
RECRUITING

Cape Town, Western Cape, 7580, South Africa
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0208)
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Health Pharma Professional Research S.A. de C.V. ( Site 0801)
RECRUITING

Mexico City, Mexico City, 03100, Mexico
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital ( Site 3322)
RECRUITING

Hiroshima, 730-8619, Japan
Hope ( Site 0413)
RECRUITING

Ribeirão Preto, São Paulo, 14026-610, Brazil
Hopital Saint Louis, Centre Hospitalier de La Rochelle ( Site 1511)
RECRUITING

La Rochelle, Charente-Maritime, 17000, France
Hospital Aleman ( Site 0301)
RECRUITING

Buenos Aires, Buenos Aires F.D., C1118AAT, Argentina
Hospital Ampang ( Site 3404)
RECRUITING

Selangor Darul Ehsan, Selangor, 68000, Malaysia
Hospital Erasto Gaertner ( Site 0401)
RECRUITING

Curitiba, Paraná, 82520-060, Brazil
Hospital General Universitario 12 de Octubre ( Site 2605)
RECRUITING

Madrid, 28041, Spain
Hospital General Universitario Dr. Balmis ( Site 2604)
RECRUITING

Alicante, Valenciana, Comunitat, 03010, Spain
Hospital Italiano de Buenos Aires ( Site 0304)
RECRUITING

CABA, C1199ABB, Argentina
Hospital Miri ( Site 3403)
RECRUITING

Miri, Sarawak, 98000, Malaysia
Hospital Nacional Dos De Mayo ( Site 0905)
COMPLETED

Lima, 15087, Peru
Hospital Nacional Edgardo Rebagliati Martins ( Site 0903)
RECRUITING

Lima, 15072, Peru
Hospital Pablo Tobon Uribe ( Site 0604)
RECRUITING

Medellín, Antioquia, 050034, Colombia
Hospital Paulistano ( Site 0406)
RECRUITING

São Paulo, 01321-001, Brazil
Hospital Universitario ""Dr. Jose Eleuterio Gonzalez"" ( Site 0802)
RECRUITING

Monterrey, Nuevo León, 64460, Mexico
Hospital Universitario Austral ( Site 0307)
RECRUITING

Pilar, Buenos Aires, B1629AHJ, Argentina
Hospital Universitario La Paz ( Site 2611)
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Miguel Servet ( Site 2607)
COMPLETED

Zaragoza, 50009, Spain
Hospital Universitario Puerta de Hierro ( Site 2615)
RECRUITING

Majadahonda, Madrid, 28222, Spain
Hospital Universitario San Ignacio ( Site 0607)
ACTIVE_NOT_RECRUITING

Bogotá, Bogota D.C., 110231, Colombia
Hospital Universitario Virgen Macarena ( Site 2608)
RECRUITING

Seville, Andalusia, 41009, Spain
Hospital Virgen de la Victoria ( Site 2609)
RECRUITING

Málaga, 29010, Spain
Hospital das Clinicas FMUSP ( Site 0402)
RECRUITING

São Paulo, 05403-010, Brazil
Hospital de Cabuenes ( Site 2613)
RECRUITING

Gijón, Principality of Asturias, 33394, Spain
Hospital de Cruces ( Site 2612)
RECRUITING

Barakaldo, Bizkaia, 48903, Spain
Hospital del Mar ( Site 2610)
RECRUITING

Barcelona, 08003, Spain
Houston Methodist Cancer Center ( Site 0154)
RECRUITING

Houston, Texas, 77030, United States
Hubei Cancer Hospital ( Site 3125)
RECRUITING

Wuhan, Hubei, 430079, China
IC La Serena Research ( Site 0504)
RECRUITING

La Serena, Coquimbo Region, 1720430, Chile
ICO L Hospitalet ( Site 2601)
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08908, Spain
IEO Istituto Europeo di Oncologia ( Site 2009)
RECRUITING

Milan, 20141, Italy
IMAT S.A.S ( Site 0603)
RECRUITING

Montería, Departamento de Córdoba, 230002, Colombia
INOC - Istituto Nazionale Oncologico Candiolo ( Site 2010)
RECRUITING

Candiolo, Torino, 10060, Italy
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 0901)
ACTIVE_NOT_RECRUITING

Surquillo, Muni Metro de Lima, 15038, Peru
IRCCS Crob ( Site 2002)
RECRUITING

Rionero in Vulture, Potenza, 85028, Italy
IRCCS Ospedale San Raffaele ( Site 2012)
RECRUITING

Milan, 20132, Italy
Icahn School of Medicine at Mount Sinai ( Site 0164)
RECRUITING

New York, New York, 10029, United States
Institut Curie - site Saint-Cloud ( Site 1501)
RECRUITING

Saint-Cloud, Île-de-France Region, 92210, France
Institute of Blood Pathology and Transfusion Medicine AMS Ukraine ( Site 2903)
RECRUITING

Lviv, Lviv Oblast, 79057, Ukraine
Institute of Hematology and Blood Diseases Hosp CAMS&PUMC ( Site 3105)
RECRUITING

Tianjin, Tianjin Municipality, 301617, China
Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 2302)
RECRUITING

Porto, 4200-072, Portugal
Instituto de Investigaciones Clinicas Mar del Plata ( Site 0306)
RECRUITING

Mar del Plata, Buenos Aires, B7600FZO, Argentina
Institutul Oncologic Cluj ( Site 2404)
RECRUITING

Cluj-Napoca, Cluj, 4003437, Romania
Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana ( Site 0178)
RECRUITING

Billings, Montana, 59102, United States
Jiangxi Cancer Hospital ( Site 3118)
RECRUITING

Nanchang, Jiangxi, 330029, China
Joe Arrington Cancer Research and Treatment Center ( Site 0183)
RECRUITING

Lubbock, Texas, 79410, United States
Juntendo University Hospital ( Site 3307)
RECRUITING

Bunkyo, Tokyo, 113-8431, Japan
Kaiser Permanente Interstate Medical Office - Central ( Site 0181)
RECRUITING

Portland, Oregon, 97227, United States
Kanazawa University Hospital ( Site 3308)
RECRUITING

Kanazawa, Ishikawa-ken, 920-8641, Japan
Kantonspital Baden ( Site 2703)
RECRUITING

Baden, Canton of Aargau, 5404, Switzerland
Karmanos Cancer Institute ( Site 0174)
RECRUITING

Detroit, Michigan, 48201, United States
Khmelnytskyi Regional Hospital ( Site 2907)
RECRUITING

Khmelnytskiy, Khmelnytskyi Oblast, 29000, Ukraine
Kindai University Hospital ( Site 3310)
RECRUITING

Sakai, Osaka, 590-0197, Japan
Kobe City Medical Center General Hospital ( Site 3318)
RECRUITING

Kobe, Hyōgo, 650-0047, Japan
Kyushu University Hospital ( Site 3313)
RECRUITING

Fukuoka, 812-8582, Japan
LIFE GROENKLOOF-Mary Potter Cancer Centre ( Site 2506)
RECRUITING

Pretoria, Gauteng, 0181, South Africa
Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC) ( Site 0206)
RECRUITING

Oshawa, Ontario, L1G 2B9, Canada
Leids Universitair Medisch Centrum ( Site 2106)
RECRUITING

Leiden, South Holland, 2333 ZA, Netherlands
Liga Norte Riograndense Contra o Cancer ( Site 0407)
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
LinYi Cancer Hospital ( Site 3104)
RECRUITING

Linyi, Shandong, 276001, China
Lutheran Hospital - Cancer Centers of Colorado ( Site 0180)
RECRUITING

Golden, Colorado, 80401, United States
MEDI-K ( Site 0701)
RECRUITING

Guatemala City, 01009, Guatemala
MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 2904)
RECRUITING

Cherkasy, Cherkasy Oblast, 18009, Ukraine
Mackay Memorial Hospital ( Site 3908)
COMPLETED

Taipei, 10449, Taiwan
Maharaj Nakorn Chiang Mai Hospital ( Site 4002)
RECRUITING

Muang, Chiang Mai, 50200, Thailand
Meander Medisch Centrum ( Site 2101)
RECRUITING

Amersfoort, Utrecht, 3813 TZ, Netherlands
MemorialCare Health System - Long Beach Medical Center ( Site 9559)
RECRUITING

Long Beach, California, 90806, United States
Mid Florida Hematology and Oncology Center ( Site 0172)
RECRUITING

Orange City, Florida, 32763, United States
Nagoya University Hospital ( Site 3309)
RECRUITING

Nagoya, Aichi-ken, 466-8560, Japan
Namık Kemal University Medical Faculty ( Site 2807)
RECRUITING

Suleymanpasa, Tekirdas, 59030, Turkey (Türkiye)
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2208)
RECRUITING

Gliwice, Silesian Voivodeship, 44-102, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2201)
COMPLETED

Warsaw, Masovian Voivodeship, 02-781, Poland
National Cancer Center Hospital East ( Site 3303)
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
National Cancer Center- Center for Hemotologic malignancy ( Site 3806)
RECRUITING

Goyang-si, Kyonggi-do, 10408, South Korea
National Cancer Centre Singapore ( Site 3701)
RECRUITING

Singapore, Central Singapore, 168583, Singapore
National Cheng Kung University Hospital ( Site 3902)
RECRUITING

Tainan, 704, Taiwan
National Hospital Organization Shikoku Cancer Center ( Site 3321)
RECRUITING

Matsuyama, Ehime, 791-0280, Japan
National Taiwan University Hospital ( Site 3901)
RECRUITING

Taipei, 10002, Taiwan
National University Hospital ( Site 3702)
RECRUITING

Singapore, Central Singapore, 119074, Singapore
Netcare Pretoria East Hospital ( Site 2502)
RECRUITING

Pretoria, Gauteng, 0181, South Africa
New York Cancer and Blood Specialists ( Site 9000)
RECRUITING

Shirley, New York, 11967, United States
New York Oncology Hematology, P.C. ( Site 0129)
RECRUITING

Albany, New York, 12206, United States
Northern Hospital ( Site 3002)
RECRUITING

Melbourne, Victoria, 3076, Australia
Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0163)
RECRUITING

Louisville, Kentucky, 40207, United States
Odense Universitetshospital ( Site 1304)
RECRUITING

Odense, Region Syddanmark, 5000, Denmark
Okayama University Hospital ( Site 3311)
RECRUITING

Okayama, 700-8558, Japan
Oncocentro Valdivia ( Site 0506)
RECRUITING

Valdivia, Los Ríos Region, 5112129, Chile
Oncologos del Occidente ( Site 0601)
RECRUITING

Pereira, Risaralda Department, 660001, Colombia
Ondokuz Mayıs Universitesi ( Site 2806)
RECRUITING

Korfez Mahallesi, Samsun, 55270, Turkey (Türkiye)
OptumCare Cancer Care ( Site 0121)
RECRUITING

Las Vegas, Nevada, 89102, United States
Orlando Health Cancer Institute ( Site 0169)
RECRUITING

Ocoee, Florida, 34761, United States
Orszagos Onkologiai Intezet ( Site 1705)
RECRUITING

Budapest, 1122, Hungary
Osaka Metropolitan University Hospital ( Site 3317)
RECRUITING

Osaka, 545-8586, Japan
Ospedale Italiano Lugano (OIL) ( Site 2705)
RECRUITING

Lugano, Canton Ticino, 6900, Switzerland
Ospedale Regionale Bellinzona e Valli ( Site 2701)
RECRUITING

Bellinzona, Canton Ticino, 6501, Switzerland
Ospedale Santa Maria delle Croci ( Site 2006)
RECRUITING

Ravenna, 48121, Italy
Owensboro Medical Health System ( Site 0195)
RECRUITING

Owensboro, Kentucky, 42303, United States
Pacific Hematology Oncology Associates ( Site 0131)
RECRUITING

San Francisco, California, 94115, United States
Peking University Third Hospital ( Site 3102)
RECRUITING

Beijing, Beijing Municipality, 100096, China
Poria Medical Center ( Site 1902)
RECRUITING

Tiberias, 15208, Israel
Pratia Onkologia Katowice ( Site 2204)
RECRUITING

Katowice, Silesian Voivodeship, 40-519, Poland
Pratia Spolka Akcyjna, Pratia Onkologia Wroclaw ( Site 2211)
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 50-019, Poland
Princess Margaret Hospital ( Site 3202)
RECRUITING

Hong Kong, Hong Kong
Prisma Health - Upstate ( Site 0158)
RECRUITING

Greenville, South Carolina, 29605, United States
Providence Medical Foundation-Oncology ( Site 0168)
RECRUITING

Fullerton, California, 92835, United States
Pusan National University Hospital ( Site 3804)
RECRUITING

Busan, Pusan-Kwangyokshi, 49241, South Korea
Queen Elizabeth Hospital ( Site 3405)
RECRUITING

Kota Kinabalu, Sabah, 88586, Malaysia
Queen Elizabeth II Health Sciences Centre ( Site 0207)
RECRUITING

Halifax, Nova Scotia, B3H 2Y9, Canada
Queen Mary Hospital ( Site 3201)
RECRUITING

Hong Kong, Hong Kong
Regionshospitalet Gødstrup ( Site 1301)
RECRUITING

Herning, Central Jutland, 7400, Denmark
Royal Adelaide Hospital ( Site 3001)
RECRUITING

Adelaide, South Australia, 5000, Australia
Royal Perth Hospital-Haematology ( Site 3004)
RECRUITING

Perth, Western Australia, 6000, Australia
SI National Research Center of Radiation Medicine, Hematology, Oncology ( Site 2901)
COMPLETED

Kyiv, 03115, Ukraine
SNPE National Cancer Institute ( Site 2902)
RECRUITING

Kyiv, 03022, Ukraine
SSM Health Dean Medical Group ( Site 0140)
RECRUITING

Madison, Wisconsin, 53715, United States
Saitama Medical University Hospital ( Site 3305)
RECRUITING

Iruma-gun, Saitama, 350-0495, Japan
Samsung Medical Center ( Site 3807)
COMPLETED

Seoul, 06351, South Korea
Sanford Cancer Center ( Site 0143)
RECRUITING

Sioux Falls, South Dakota, 57104, United States
Sanford Health Roger Maris Cancer Center ( Site 0189)
RECRUITING

Fargo, North Dakota, 58102, United States
Sarawak General Hospital ( Site 3402)
RECRUITING

Kuching, Sarawak, 93586, Malaysia
Semmelweis University-Belgyógyászati és Hematológiai Klinika ( Site 1703)
RECRUITING

Budapest, Hajdú-Bihar, 1088, Hungary
Severance Hospital, Yonsei University Health System ( Site 3802)
COMPLETED

Seoul, 03722, South Korea
Shandong Cancer Hospital ( Site 3108)
RECRUITING

Jinan, Shandong, 250117, China
Shanxi Cancer Hospital ( Site 3106)
RECRUITING

Taiyuan, Shanxi, 030013, China
Sichuan Cancer Hospital. ( Site 3111)
RECRUITING

Chengdu, Sichuan, 610041, China
Sourasky Medical Center ( Site 1904)
RECRUITING

Tel Aviv, 6423906, Israel
Spital Judetean Sibiu ( Site 2405)
RECRUITING

Sibiu, 557260, Romania
Spitalul Clinic Colțea ( Site 2401)
COMPLETED

Bucharest, Bucharest, 030171, Romania
St.Mary's H., Youido ( Site 3805)
RECRUITING

Seoul, 07345, South Korea
Sun Yat-sen University Cancer Center ( Site 3121)
RECRUITING

Guangzhou, Guangdong, 510060, China
Sunnybrook Research Institute ( Site 0204)
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Sunway Medical Centre ( Site 3406)
RECRUITING

Petaling Jaya, Selangor, 47500, Malaysia
Szabolcs Szatmár Bereg Vármegyei Oktatókórház ( Site 1704)
RECRUITING

Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary
Szpital Kliniczny Ministerstwa Spraw Wewnętrznych i Administracji z Warmińsko-Mazurskim Centrum Onko ( Site 2205)
RECRUITING

Olsztyn, Warmian-Masurian Voivodeship, 10-228, Poland
The Affiliated Hospital of Guizhou Medical University ( Site 3112)
RECRUITING

Guiyang, Guizhou, 550004, China
The First Affiliated Hospital of Xiamen University ( Site 3120)
RECRUITING

Xiamen, Fujian, 361003, China
The First Affiliated Hospital, Zhejiang Medical University ( Site 3116)
RECRUITING

Hangzhou, Zhejiang, 310009, China
The First Hospital Of Jilin University ( Site 3103)
RECRUITING

Changchun, Jilin, 130021, China
The University of Arizona Cancer Center - North Campus ( Site 0124)
RECRUITING

Tucson, Arizona, 85719, United States
The University of Mississippi Medical Center ( Site 0161)
RECRUITING

Jackson, Mississippi, 39216, United States
The University of Tennessee Medical Center ( Site 0142)
RECRUITING

Knoxville, Tennessee, 37920, United States
Tohoku University Hospital ( Site 3301)
RECRUITING

Sendai, Miyagi, 980-8574, Japan
Tokai University Hospital ( Site 3302)
RECRUITING

Isehara, Kanagawa, 259-1193, Japan
Tokyo Metropolitan Komagome Hospital ( Site 3323)
RECRUITING

Bunkyo, Tokyo, 113-8677, Japan
Tolna Vármegyei Balassa János Kórház ( Site 1710)
RECRUITING

Szekszárd, Tolna County, 7100, Hungary
Townsville University Hospital ( Site 3006)
RECRUITING

Townsville, Queensland, 4814, Australia
Tri-Service General Hospital ( Site 3906)
RECRUITING

Taipei, 114, Taiwan
Trinity Health Saint Joseph Mercy Hospital Ann Arbor ( Site 9545)
RECRUITING

Ann Arbor, Michigan, 48106, United States
Truman Medical Center ( Site 0122)
RECRUITING

Kansas City, Missouri, 64108, United States
USA Mitchell Cancer Institute ( Site 0173)
RECRUITING

Mobile, Alabama, 36604, United States
Unidade Local de Saude de Braga - Hospital de Braga ( Site 2306)
RECRUITING

Braga, 4710-243, Portugal
Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 2308)
RECRUITING

Lisbon, 1649-035, Portugal
Universal Clinic Oberig ( Site 2908)
COMPLETED

Kyiv, 03057, Ukraine
University Cancer & Blood Center, LLC ( Site 0141)
RECRUITING

Athens, Georgia, 30607, United States
University College Hospital, Department of Haematology ( Site 1303)
RECRUITING

Aarhus, Central Jutland, 8200, Denmark
University General Hospital of Alexandroupoli ( Site 1601)
RECRUITING

Alexandroupoli, Evros, 681 00, Greece
University Hospital,Kyoto Prefectural University of Medicine ( Site 3315)
RECRUITING

Kyoto, 602-8566, Japan
University of Kentucky ( Site 0106)
RECRUITING

Lexington, Kentucky, 40536, United States
University of Miyazaki Hospital ( Site 3319)
RECRUITING

Miyazaki, 889-1692, Japan
University of Virginia Cancer Center ( Site 0138)
RECRUITING

Charlottesville, Virginia, 22903, United States
University of Yamanashi Hospital ( Site 3320)
RECRUITING

Chūō, Yamanashi, 409-3898, Japan
Uniwersytecki Szpital Kliniczny nr 1 w Lublinie ( Site 2202)
RECRUITING

Lublin, Lublin Voivodeship, 20- 081, Poland
Virginia Cancer Institute ( Site 0148)
RECRUITING

Richmond, Virginia, 23229, United States
Vista Oncology ( Site 4201)
RECRUITING

Olympia, Washington, 98506, United States
West China Hospital, Sichuan University ( Site 3110)
RECRUITING

Chengdu, Sichuan, 610041, China
Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku ( Site 2210)
RECRUITING

Słupsk, Pomeranian Voivodeship, 76-200, Poland
Yamagata University Hospital ( Site 3312)
RECRUITING

Yamagata, 990-9585, Japan
Yunnan Province Cancer Hospital ( Site 3109)
RECRUITING

Kunming, Yunnan, 650118, China
Zhujiang Hospital of Southern Medical University ( Site 3122)
RECRUITING

Guangzhou, Guangdong, 510280, China

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