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New drug YOLT-202 tested for rare lung and liver disease

NCT ID NCT07193615

First seen Oct 31, 2025 · Last updated May 19, 2026 · Updated 33 times

Summary

This early-phase study tests a single dose of YOLT-202 in 18 adults with Alpha-1 antitrypsin deficiency (AATD), a genetic condition that can damage the lungs and liver. The main goal is to check if the drug is safe and to find the best dose. Participants must have the severe PiZZ genetic type and low AAT levels.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Ren Ji Hospital Affiliated to Shanghai Jiao Tong University

    Shanghai, China

Conditions

Explore the condition pages connected to this study.