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Can yoga rewire the brain to ease lasting grief in older adults?

NCT ID NCT07738133

Symptom relief Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This study explores whether Iyengar yoga can reduce symptoms of prolonged grief disorder in adults aged 40 and older who have lost a loved one. Participants will take part in weekly yoga classes or a health education group, and researchers will measure changes in grief severity and brain activity. The goal is to understand how yoga might help the brain adapt after loss and potentially offer a new way to support those struggling with grief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Iyengar Yoga
What this could lead to
If yoga proves effective, it could offer a non-drug way to ease prolonged grief in older adults and reveal brain targets for new therapies.
What could go wrong
This is an early-stage trial, so results may not be conclusive. Yoga may not outperform the control group, and benefits could vary by individual.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 126 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Jun 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 89 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female greater than or equal to 40 years of age * Bereavement \>6 months * Score greater than or equal to 25 on the Inventory of Complicated Grief (ICG) * Presence of PGD (subsyndromal and syndromal) * Adequate visual and auditory acuity Exclusion Criteria: * Delirium/unstable medical conditions * Lifetime history of neurological illnesses: seizures, stroke, dementia of any -etiology, severe head injury, brain tumor or surgery * Serious back, joint or neck injuries within the past 3 months * Currently practicing yoga * Gross structural abnormalities on T1-weighted images * Lifetime history of the following psychiatric disorders: bipolar or psychotic -disorders, including psychotic depression * Current alcohol/drug abuse or dependence * Magnetic resonance imaging (MRI) contraindications * Acute suicidality

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Conditions

The condition(s) this trial relates to.

Health Education Prolonged Grief Disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Prolonged grief disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.