Your voice may reveal hidden exhaustion: new study tests AI fatigue detection
NCT ID NCT07033559
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This observational study will test whether computer analysis of voice recordings can detect a deep type of exhaustion called central fatigue in people with generalised myasthenia gravis. 240 adults in the US and UK will record themselves speaking twice daily, twice a week for 4 weeks, and answer short questionnaires. The goal is to see if voice patterns can reliably signal fatigue, potentially enabling remote monitoring.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a simple, remote way to monitor fatigue in myasthenia gravis using just a voice recording.
- What could go wrong
- This is an early observational study, not a treatment trial. The voice analysis may not be accurate enough, or patients may find daily recordings burdensome.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 240 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of a convenience sample of adults with generalised Myasthenia Gravis recruited through a decentralised, multi-channel approach across the United States and United Kingdom. This remote recruitment strategy leverages established myasthenia gravis patient networks, charities and digital platforms like social media groups to reach geographically dispersed participants. The decentralised methodology is particularly appropriate for studying a rare condition where patients may have limited mobility due to fatigue and muscle weakness.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults ≥18 years old * Self-reported generalised Myasthenia Gravis diagnosis confirmed by healthcare provider for ≥6 months * Disease stability for ≥6 months (no hospitalisations, medication changes, or significant symptom worsening) * English as first language * Residence in US or UK * Vision adequate for screen reading (with aid or correction if necessary) * Access to internet-connected device with compatible browser and microphone * Adequate internet connectivity (≥5 Mbps download, ≥3 Mbps upload) * Ability to complete twice-daily assessments during specified time windows * Signed electronic informed consent Exclusion Criteria: * Pure ocular Myasthenia Gravis * Diagnosed mild cognitive impairment or dyslexia * Speech or hearing impairments affecting voice recording * Unable to provide credible diagnostic information (healthcare provider diagnosis, antibody test results, current medications) * Major inconsistencies in reported medical history * Unsigned informed consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
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The official record
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