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Could vitamin d help stop bedwetting? new trial tests the idea

NCT ID NCT07292753

Disease control Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 90 children aged 6 to 12 with night-time bedwetting and low vitamin D levels. It compared three treatments: vitamin D alone, desmopressin alone, or both together. The goal was to see which approach reduced wet nights the most over 3 to 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin D and desmopressin
What this could lead to
If successful, this could show that vitamin D supplementation alone or combined with desmopressin is a safe and effective way to reduce bedwetting in children with low vitamin D levels.
What could go wrong
This is a small, completed trial with only 90 children, so results may not apply to all kids. Also, vitamin D deficiency may not be the main cause of bedwetting for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Dec 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 12 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children and adolescents aged 6 to 12 years * Primary monosymptomatic nocturnal enuresis * At least 2 episodes of night-time bedwetting per week for ≥3 consecutive months * Serum 25-hydroxyvitamin D level \<20 ng/mL * Normal kidney function * Normal serum sodium level * Absence of daytime lower urinary tract symptoms (urgency, frequency, dysuria) * Informed consent from parent or guardian and assent from the child when appropriate Exclusion Criteria: * Non-monosymptomatic nocturnal enuresis (daytime storage or voiding symptoms) * Congenital urinary tract anomalies (e.g., meatal stenosis, hypospadias, epispadias) * Urinary tract infection until culture becomes negative * Neurological abnormalities, including suspected neurogenic bladder * Endocrine diseases such as diabetes mellitus or hyperthyroidism * Congestive heart failure or significant cardiac disease * Prior or current use of vitamin D supplementation * Serum sodium below normal range * Chronic systemic illness * Any condition judged by investigators to interfere with study participation

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Conditions

The condition(s) this trial relates to.

nocturnal enuresis vitamin D deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nocturnal enuresis Vitamin D deficiency

Contacts and locations

Locations

  • Ain Shams University Hospitals

    Cairo, Cairo Governorate, 11511, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.