Can vitamin d speed healing of bed sores in the ICU?
NCT ID NCT07813975
First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time
Summary
Researchers are testing whether high-dose vitamin D helps heal bed sores in patients admitted to intensive care units. The trial enrolls 50 critically ill adults with low vitamin D levels and grade 1 or 2 pressure ulcers. Participants receive 50,000 IU of vitamin D3 in milk daily for five days, and researchers track wound healing and vitamin D levels over one week.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Vitamin D3 (cholecalciferol)
- What this could lead to
- If it works, this could offer a simple, low-cost way to help bed sores heal faster in people who are seriously ill in intensive care.
- What could go wrong
- This is a small, early trial with only 50 patients, so the results may not hold up in larger studies. High-dose vitamin D can raise calcium levels, which may cause problems, especially in people who are already very sick.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2026
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
inclusion criteria: 1-Critically ill patients with bed sores Grade (1-2), (non-light) exudate admitted to ICUs. 2- Serum vitamin D \<20 ng/mL. 3- Both genders. 4- Age: 18-60 years. 5- enteral access in place to enable delivery of vitamin D3 and are deemed to be able to tolerate enteral drug administration. 6- GCS \> 9. 7- Serum Calcium (8-10 mg/dl). 8- Serum creatinine less than 1.4 mg/dL. exclusion criteria: 1. Refusal of the legal guardian of the patient to participate in the study. 2. Current pregnancy or lactating mother. 3. Patients who are terminally ill and expected to die in less than 72 hours. 4. Renal dysfunction (GFR \< 30 mL/min) and the onset of dialysis during the study. 5. Vitamin D supplementation in the last 15 days. 6. Hypo/hyper-calcemia (adjusted calcium less than 8 mg/dL or above 10). 7. History of disorders associated with hypercalcemia (history of cancer with history of hypercalcemia within the past 1 year, hyperparathyroidism, sarcoidosis, nephrolithiasis). 8. History of parathyroid dysfunction. 9. Ongoing shock, \[defined as unstable blood pressure despite vasopressor support and mean arterial pressure (MAP) \< 60 mm Hg on at least 3 consecutive readings within a 3-hour period prior to study entry\]. 10. History of malabsorption syndromes; gastrointestinal intolerance (diarrhea, vomiting, or increased nasogastric aspirates). 11\. History of adverse reaction to vitamin D supplementation. 12. known history of cirrhosis. 13. Patients taking any medications that have serious drug interactions with vitamin D like statins, orlistat, aluminum hydroxide (interfere with the absorption of vitamin D), digoxin (can enhance the effects of vitamin D on the heart leading to potential toxicity), and certain diuretics (can cause high calcium levels).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Ain Shams University
RECRUITINGCairo, Egypt