Heart spasm study tests vitamins and statins – but ends early
NCT ID NCT03228238
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether long-term treatment with vitamin C+E and statins could reduce artery spasms and plaque buildup in people with variant angina, a type of chest pain. The trial planned to enroll 320 adults aged 30 and older, but it was terminated early. The main goal was to see if these treatments improve blood vessel function and reduce spasm severity over several years.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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320 people
The number who actually took part.
- Started
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Sep 2014
- Finished
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Jun 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subject must be at least 30 years of age. 2. Subject is able to verbally confirm understandings of risks, benefits and treatment alternatives of receiving the Vitamin C+E or Statin or Dual, and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure. 3. Subject must have symptoms that are consistent with vasospastic angina with planned Coronary angiography and Provocation test. Exclusion Criteria: 1. Patient who has organic coronary stenosis in main coronary branch at least 50% luminal narrowing after intracoronary nitroglycerin injection 2. Patient who has continuously taken Vitamin C or Vitamin E or Statin within 3months before Admission 3. Creatinine level ≥ 2.0mg/dL or dependence on dialysis. 4. Severe hepatic dysfunction (AST and ALT: 3 times upper normal reference values). 5. Active Myopathy or elevated Creatine kinase enzyme level (3 times upper normal reference values). 6. History of Severe hepatic dysfunction or Rhabdomyolysis due to statin side effect 7. Female of childbearing potential, unless a recent pregnancy test is negative, who possibly plan to become pregnant any time after enrollment into this study. 8. History of Urolithiasis 9. Non-cardiac co-morbid conditions are present with life expectancy \<1 year or that may result in protocol non-compliance (per site investigator's medical judgment).
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Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Seoul National University Hospital
Seoul, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.