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Vitamin a pills tested as possible scoliosis treatment for kids

NCT ID NCT07335991

Disease control Sponsor: Second Affiliated Hospital of Wenzhou Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether giving vitamin A supplements to children with low vitamin A levels can slow the worsening of scoliosis (curved spine). The trial will include 140 children aged 6 to 15 who have mild to moderate scoliosis and are still growing. Half will get vitamin A plus nutrition advice, the other half only nutrition advice. Researchers will measure spine curves and quality of life over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin A supplements
What this could lead to
If it works, this could point toward a simple, low-cost way to slow scoliosis worsening in children with low vitamin A.
What could go wrong
This is a small, early-stage trial. Vitamin A deficiency is just one possible factor, and supplements may not affect curve progression. Results may not apply to all children with scoliosis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 15 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age between 6 and 15 years. 2. Biochemically confirmed vitamin A deficiency (serum retinol \< 0.20 mg/L) or insufficiency (serum retinol 0.20-0.29 mg/L). 3. Has undergone radiographic evaluation (standing full-spine X-ray) for idiopathic scoliosis at the initial clinic visit. 4. Skeletally immature (Risser sign 0-3) with a major Cobb angle \< 40 degrees at baseline. 5. Written informed consent/assent provided by the participant and legal guardian. Exclusion Criteria: 1. Unwillingness or inability to comply with all study procedures and follow-up visits. 2. Plans to relocate outside the study area within the next 24 months. 3. Previous high-dose vitamin A supplementation therapy within the past 12 months. 4. Clinical signs of severe vitamin A deficiency syndrome (e.g., xerophthalmia, Bitot's spots). 5. Serum vitamin A level \> 0.70 mg/L (to avoid risk of hypervitaminosis A). 6. Severe chronic health conditions that could confound study outcomes, including but not limited to: * Known syndromic, neuromuscular, or congenital musculoskeletal causes of scoliosis. * History of spine surgery or significant spinal trauma. * Spinal tumor. * Leg length discrepancy \> 20 mm. * Other severe chronic diseases (e.g., poorly controlled diabetes, chronic liver or renal disease, malabsorption syndromes). * Severe obesity (body mass index z-score ≥ 3).

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Conditions

The condition(s) this trial relates to.

idiopathic scoliosis vitamin A deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Idiopathic scoliosis Vitamin A deficiency

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Second Affiliated Hospital of Wenzhou Medical University

    RECRUITING

    Wenzhou, Zhejiang, 325000, China

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