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Video games tested as depression treatment in large study

NCT ID NCT05426265

Symptom relief Sponsor: Aalto University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether playing specially designed video games (MEL-T01 and MEL-S01) for 12 weeks could reduce depression symptoms in adults with major depressive disorder. Over 1000 participants were assigned to either the game therapy or usual care. The main goal was to see if depression scores improved more with the games.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MEL-T01 and MEL-S01 (game-based digital therapy software devices)
What this could lead to
If it works, this could offer a new, engaging way to help ease depression symptoms without medication.
What could go wrong
This is a completed study, but results are not yet widely confirmed. The effect may be small or not better than usual care. Digital games may not work for everyone with depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,001 people

The number who actually took part.

Started

Jun 2022

Finished

Aug 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between 18-65 year-old * Suffering from major depressive disorder * Have an ongoing mental health treatment contact to basic healthcare, specialised healthcare, student healthcare or occupational healthcare * Has sufficient eyesight with or without prescription * Has a Windows computer with internet connection and mouse * Has email and phone number Exclusion Criteria: * They have threat of self-harm * They have addiction to digital games * They have psychotic disorders * They are pregnant or breastfeeding * They have impaired ability in decision making * They are prisoner or forensic subject * They have neurological disorders such as epilepsy or brain injury

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major depressive disorder

Contacts and locations

Locations

  • Aalto University (TMS)

    Espoo, Uusimaa, 02150, Finland

  • Aalto University, Department of Neuroscience and Biomedical Engineering

    Espoo, Uusimaa, 02150, Finland

  • Helsinki University Hospital BioMag laboratory

    Helsinki, Uusimaa, 00029, Finland

  • Helsinki University Hospital, Psychiatry

    Helsinki, Uusimaa, 00014, Finland

  • Turku University Hospital

    Turku, Southwest Finland, 20521, Finland

  • University of Helsinki Neuroscience Center (MEG, MRI)

    Helsinki, Uusimaa, Finland

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