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New study investigates hidden heart risks in down syndrome

NCT ID NCT07630207

Knowledge-focused Sponsor: University of Nevada, Las Vegas Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at blood vessel health in adults with Down syndrome (ages 18-35) compared to adults without Down syndrome. Researchers want to find out if people with Down syndrome have hidden changes in their blood vessels that could raise their risk for heart disease or stroke. Participants will have simple, non-invasive tests to measure how well their blood vessels work. The results may help doctors better understand heart risks and promote healthier aging in this group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The population being evaluated by the protocol consists of a convenience sample of individuals with Down syndrome (Ds) between the ages of 18 and 35 years old, and a group of controls without Ds matched for age and sex, living in the community. 24 participants will be enrolled in the study at UNLV; 12 individuals with Down syndrome and 12 individuals without Down syndrome.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * between 18 and 35 years old * generally healthy * sedentary (defined as being involved in less than 30 minutes of moderately-intense physical activity per day) Additionally, for the participants with Down syndrome: * diagnosis of Down syndrome trisomy 21 * normal thyroid function or stable thyroid function (and medications) for at least 6 mo. Exclusion Criteria: * unresolved congenital heart disease; * atherosclerotic or other vascular disease (such as blood clot history or clotting disorders); * asthma or other pulmonary disease; * hypertension (defined BP \>140/90 mmHg); blood pressure below 90/60 mmHg; * history of pre-syncope or syncope; * diabetes (defined as Hba1c of \>7.5% or use of glucose lowering medication); * severe obesity (defined as BMI \>40); * heart medications affecting heart rate, blood pressure or arterial function, including blood thinners; anti-inflammatory medication including NSAIDS; * current smoking; * currently pregnant or planning to become pregnant during the study period; * currently breastfeeding; * unable or unwilling to use an acceptable method of contraception during the study timeframe; * positive pregnancy test at screening.

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Conditions

The condition(s) this trial relates to.

Down syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Down syndrome (trisomy 21)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Nevada Las Vegas - UNLV

    RECRUITING

    Las Vegas, Nevada, 89154, United States

More trials for these conditions

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