Vaginal ring tested for safety in overweight PCOS women
NCT ID NCT04257500
First seen Jan 11, 2026 · Last updated Jun 23, 2026 · Updated 27 times
Summary
This study looked at whether using a contraceptive vaginal ring (NuvaRing) for 16 weeks affects the risk of metabolic syndrome in overweight or obese women with polycystic ovary syndrome (PCOS). Researchers enrolled 22 participants and measured changes in blood pressure, waist size, blood sugar, and cholesterol. The goal was to see if this birth control method is safe for this specific group.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
etonogestrel/ethinyl estradiol vaginal ring (NuvaRing)
What this could lead to
If successful, this could show that the vaginal ring is a safe contraceptive option for overweight/obese women with PCOS without raising metabolic syndrome risk.
What could go wrong
This was a small, completed Phase 4 study with only 22 participants, so results may not apply to all women. The ring may still affect cholesterol or blood pressure in some individuals.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.