New vaccine combo aims to boost cancer fight in lung and esophageal patients
NCT ID NCT04908111
First seen Apr 14, 2026 · Last updated Jun 09, 2026 · Updated 10 times
Summary
This early-phase trial tests two experimental vaccines (ChAdOx1 and MVA) designed to help the immune system target cancer proteins MAGE-A3 and NY-ESO-1. About 15 adults with advanced non-small cell lung cancer or squamous esophageal cancer will receive the vaccines alongside their usual chemotherapy and an immune checkpoint inhibitor. The main goal is to check safety and tolerability, with a secondary focus on how long the disease stays under control.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom
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Blackpool Victoria Hospital
Blackpool, United Kingdom
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Churchill Hospital
Oxford, United Kingdom
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Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom
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Leicester Royal Infirmary
Leicester, United Kingdom
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Royal Preston Hospital
Preston, United Kingdom
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Southampton General Hospital
Southampton, United Kingdom
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St James's University Hospital
Leeds, United Kingdom
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The Christie NHS Foundation Trust
Manchester, United Kingdom
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.