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New hope for eczema sufferers: drug switch trial launches

NCT ID NCT06389136

Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study tests whether upadacitinib, an oral tablet, can help adults with moderate to severe eczema (atopic dermatitis) who didn't get enough relief from dupilumab injections. About 200 participants will be randomly assigned to take upadacitinib or continue dupilumab for 8 weeks, then may switch doses based on response. The goal is to see if upadacitinib can better control skin symptoms and itching.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Upadacitinib (oral tablet)
What this could lead to
If successful, this could offer a new treatment option for people with eczema who haven't gotten enough relief from dupilumab.
What could go wrong
This is an early-stage trial with only 200 participants, so results may not apply to everyone. Upadacitinib also has known side effects like infections and allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 63 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Chronic AD with onset of symptoms at least 3 years prior to Baseline and subject meets Hanifin and Rajka criteria. * Participant meets all the following disease activity criteria at Baseline Visit: * Eczema Area and Severity Index (EASI) score \>= 12; * validated Investigator´s Global Assessment for AD (vIGA-AD) score \>= 3; * Body surface area (BSA) involvement of \>= 10% in a majority of subjects (\>= 50% of the overall study population) * Baseline weekly average of daily Worst Pruritus-Numerical Rating Scale (WP-NRS) \>= 4. Note: The Baseline weekly average of daily WP-NRS will be calculated from the 7 consecutive days immediately preceding the Baseline Visit. A minimum of 4 daily scores out of the 7 days is needed. * Inadequate response to dupilumab treatment after at least 4 months of current use. * Particpant has applied a topical emollient (an additive-free, bland emollient moisturizer) twice daily for at least 7 days before the Baseline Visit and for the duration of the study. Note: Subject may use prescription moisturizers or moisturizers containing ceramide, urea, filaggrin degradation products or hyaluronic acid if such moisturizers were initiated before the Screening visit. Exclusion Criteria: * Meeting any of the following conditions at Baseline: * Other active skin diseases or skin infections (bacterial, fungal, or viral) requiring systemic treatment within 4 weeks of the Baseline Visit or would interfere with assessment of AD lesions; * Two or more past episodes of herpes zoster, or one or more episodes of disseminated herpes zoster; * One or more past episodes of disseminated herpes simplex (including eczema herpeticum); * HIV infection defined as confirmed positive anti- HIV Ab test; * Participants with current or past history of infection including, Evidence of Hepatitis B virus (HBV) or Hepatitis C virus (HCV); * Active TB or meet TB exclusionary parameters (specific requirements for TB testing are provided in the operations manual); * For Japan: Positive result of beta-D-glucan (screening for Pneumocystis jirovecii infection) or two consecutive indeterminate results of beta-D-glucan during the Screening Period; * Active infection(s) requiring treatment with intravenous anti-infectives within 30 days, or oral/intramuscular anti-infectives within 14 days prior to the Baseline Visit; * Chronic recurring infection and/or active viral infection that, based on the investigator's clinical assessment, makes the subject an unsuitable candidate for the study; * COVID-19 infection: In subjects who tested positive for COVID-19, at least 5 days must have passed between a COVID-19 positive test result and the Baseline visit of asymptomatic subjects. Subjects with mild/moderate COVID-19 infection can be enrolled if fever is resolved without use of antipyretics for 24 hours and other symptoms improved, or if 5 days have passed since the COVID-19 positive test result (whichever comes last). Subjects may be rescreened if deemed appropriate by the investigator based upon the subject's health status. * At Baseline any of the following medical diseases or disorders: * Recent (within past 6 months) cerebrovascular accident, myocardial infarction, coronary stenting, and aorto-coronary bypass surgery or venous thromboembolism; * Any unstable clinical condition which, in the opinion of the investigator would put the subject at risk by participating in the protocol; * Diagnosed active parasitic infection, suspected or high risk of parasitic infection unless clinical (and if necessary) laboratory assessment have ruled out active infection before randomization; * History of an organ transplant which requires continued immunosuppression; * History of an allergic reaction or significant sensitivity to constituents of the study drug (and its excipients) and/or other products in the same class; * History of GI perforation (other than due to appendicitis or mechanical injury), diverticulitis, or significantly increased risk for GI perforation per investigator judgment; * Conditions that could interfere with drug absorption including but not limited to short bowel syndrome or gastric bypass surgery including sleeve gastrectomy; subjects with a history of gastric banding/segmentation are not excluded; * History of malignancy except for successfully treated NMSC or localized carcinoma in situ of the cervix.

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Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atopic dermatitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    109 sites in 9 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • ASL 1 Abruzzo - Ospedale regionale San Salvatore /ID# 278461

    RECRUITING

    L’Aquila, L Aquila, 67100, Italy

  • Advanced Dermatology And Cosmetic Surgery - Spartanburg /ID# 267185

    RECRUITING

    Spartanburg, South Carolina, 29307, United States

  • Ajou University Hospital - Suwon-si /ID# 263328

    RECRUITING

    Suwon, Gyeonggido, 16499, South Korea

  • Allergy & Asthma Associates of Southern California - Mission Viejo /ID# 266574

    RECRUITING

    Mission Viejo, California, 92691, United States

  • Alliance Clinical Research of Tampa /ID# 264531

    RECRUITING

    Tampa, Florida, 33615, United States

  • Apex Clinical Trials /ID# 263747

    COMPLETED

    Brandon, Florida, 33511, United States

  • Arlington Research Center, Inc /ID# 263665

    RECRUITING

    Arlington, Texas, 76011, United States

  • BRCR Global - Katy /ID# 267304

    RECRUITING

    Katy, Texas, 77450, United States

  • Beacon Clinical Research /ID# 263843

    RECRUITING

    Quincy, Massachusetts, 02169, United States

  • Bellaire Dermatology Associates /ID# 263794

    COMPLETED

    Bellaire, Texas, 77401, United States

  • Beth Israel Deaconess Medical Center /ID# 263703

    COMPLETED

    Boston, Massachusetts, 02215, United States

  • Boston Specialists /ID# 265810

    RECRUITING

    Boston, Massachusetts, 02111-1901, United States

  • Cahaba Dermatology & Skin Health Center /ID# 263855

    RECRUITING

    Birmingham, Alabama, 35244, United States

  • Caribbean Medical Research Center Headlands /ID# 267163

    RECRUITING

    San Juan, 00918-3501, Puerto Rico

  • Centre de Recherche Saint-Louis /ID# 271083

    COMPLETED

    Québec, Quebec, G1W 4R4, Canada

  • Centre de Recherche dermatologique du Quebec Metropolitain /ID# 277564

    RECRUITING

    Québec, Quebec, G1V 4X7, Canada

  • Centricity Research Columbus Dermatology /ID# 266529

    RECRUITING

    Columbus, Georgia, 31904, United States

  • Centro Integral de Reumatología del Caribe SAS - Circaribe SAS /ID# 265088

    RECRUITING

    Barranquilla, Atlántico, 80002, Colombia

  • Centro de Inmunología y Genética CIGE SAS /ID# 266200

    RECRUITING

    Medellín, Antioquia, 050012, Colombia

  • Centro de Investigacion en Reumatologia y especialidades Medicas S.A.S- CIREEM /ID# 265092

    RECRUITING

    Bogotá, Cundinamarca, 110221, Colombia

  • Clearlyderm Dermatology - West Boca /ID# 264923

    COMPLETED

    Boca Raton, Florida, 33428, United States

  • Cleaver Medical Group Dermatology /ID# 263788

    RECRUITING

    Dawsonville, Georgia, 30534, United States

  • Clinical Research Puerto Rico /ID# 263197

    RECRUITING

    San Juan, 00909-1711, Puerto Rico

  • Clinical Research of Philadelphia /ID# 264972

    RECRUITING

    Philadelphia, Pennsylvania, 19114, United States

  • Clinical Trials Institute - Northwest Arkansas /ID# 267290

    RECRUITING

    Fayetteville, Arkansas, 72703, United States

  • Clinical Trials Research Institute /ID# 263846

    RECRUITING

    Thousand Oaks, California, 91320, United States

  • Comprehensive Dermatology Center of Pasadena /ID# 281014

    RECRUITING

    Pasadena, California, 91105, United States

  • Consorci Hospital General Universitario de Valencia /ID# 278306

    RECRUITING

    Valencia, 46014, Spain

  • Dartmouth Hitchcock Medical Center - Old Etna Road /ID# 263840

    RECRUITING

    Lebanon, New Hampshire, 03766, United States

  • Dawes Fretzin /ID# 264534

    COMPLETED

    Indianapolis, Indiana, 46256, United States

  • DeNova Research /ID# 264513

    RECRUITING

    Chicago, Illinois, 60610, United States

  • Dermatologist Medical Group of North County- Profound Research /ID# 266512

    RECRUITING

    Oceanside, California, 92056, United States

  • Dermatology Associates of Plymouth Meeting /ID# 267286

    RECRUITING

    Plymouth Meeting, Pennsylvania, 19462, United States

  • Dermatology Associates of Tyler /ID# 264980

    RECRUITING

    Tyler, Texas, 75703, United States

  • Dermatology Research Institute - Blackfoot Trail /ID# 270450

    RECRUITING

    Calgary, Alberta, T2J 7E1, Canada

  • Dermatology Specialists Research (DS Research) - Kentucky /ID# 263388

    COMPLETED

    Louisville, Kentucky, 40241, United States

  • Dermatology Treatment and Research Center /ID# 265812

    RECRUITING

    Dallas, Texas, 75230, United States

  • Dokkyo Medical University Hospital /ID# 265431

    RECRUITING

    Mibu, Tochigi, 321-0293, Japan

  • Dr Tirziu Dermato-Chirurgie SRL /ID# 278661

    RECRUITING

    Timișoara, Timiș County, 300188, Romania

  • Encore Medical Research - Weston /ID# 278491

    RECRUITING

    Weston, Florida, 33331, United States

  • Equity Medical /ID# 265814

    RECRUITING

    New York, New York, 10023-7340, United States

  • Exalt Clinical Research /ID# 281611

    RECRUITING

    Chula Vista, California, 91910, United States

  • FAX Pharma Clinical Research /ID# 280915

    RECRUITING

    Miami, Florida, 33146, United States

  • FXM Clinical Research Ft. Lauderdale /ID# 280911

    RECRUITING

    Fort Lauderdale, Florida, 33308, United States

  • First OC Dermatology /ID# 263349

    RECRUITING

    Fountain Valley, California, 92708, United States

  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 278463

    RECRUITING

    Milan, 20122, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 278460

    RECRUITING

    Rome, Roma, 00168, Italy

  • Forest Hills Dermatology Group @ Union Turnpike /ID# 263755

    COMPLETED

    Kew Gardens, New York, 11415, United States

  • FutureMeds S.R.L. /ID# 279203

    RECRUITING

    Galati, 800183, Romania

  • FutureMeds S.R.L. /ID# 279217

    RECRUITING

    Galati, 800183, Romania

  • Fxm Clinical Research - Miramar /ID# 280934

    RECRUITING

    Miramar, Florida, 33027, United States

  • GCM Medical Group, PSC /ID# 263218

    RECRUITING

    San Juan, 00917, Puerto Rico

  • GSI Clinical Research, LLC /ID# 263760

    RECRUITING

    Margate, Florida, 33063-7011, United States

  • Georgia Skin & Cancer Clinic /ID# 267199

    COMPLETED

    Savannah, Georgia, 31419, United States

  • Global Clinical Professionals (GCP) /ID# 266474

    RECRUITING

    St. Petersburg, Florida, 33705, United States

  • Great Lakes Research Group - Bay City /ID# 263535

    COMPLETED

    Bay City, Michigan, 48706, United States

  • Health Concepts /ID# 263383

    RECRUITING

    Rapid City, South Dakota, 57702, United States

  • Henry Ford Medical Center - New Center One /ID# 263522

    RECRUITING

    Detroit, Michigan, 48202-3046, United States

  • Hospital Universitari i Politecnic La Fe /ID# 278307

    RECRUITING

    Valencia, 46026, Spain

  • Hospital Universitario 12 de Octubre /ID# 278315

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario Virgen de las Nieves /ID# 278316

    RECRUITING

    Granada, 18014, Spain

  • Hospital Universitario de La Princesa /ID# 278319

    RECRUITING

    Madrid, 28006, Spain

  • IRCCS Istituto Clinico Humanitas /ID# 278458

    RECRUITING

    Rozzano, Lombardy, 20089, Italy

  • Ichinomiya Municipal Hospital /ID# 265068

    RECRUITING

    Ichinomiya, Aichi-ken, 491-8558, Japan

  • Integrative Skin Science and Research /ID# 264537

    RECRUITING

    Sacramento, California, 95815, United States

  • International Dermatology Research /ID# 264961

    RECRUITING

    Miami, Florida, 33144, United States

  • Katahira Dermatology Urology Clinic /ID# 264403

    RECRUITING

    Kagoshima, 890-0063, Japan

  • Kawasaki Medical School Hospital /ID# 266164

    RECRUITING

    Kurashiki, Okayama-ken, 701-0192, Japan

  • Konkuk University Medical Center /ID# 263327

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 05030, South Korea

  • Korea University Ansan Hospital /ID# 263330

    RECRUITING

    Ansan-si, Gyeonggido, 15355, South Korea

  • Las Vegas Dermatology /ID# 265801

    RECRUITING

    Las Vegas, Nevada, 89144, United States

  • Lenus Research and Medical Group /ID# 263779

    RECRUITING

    Miami, Florida, 33172, United States

  • Life Clinical Trials - Coral Springs /ID# 267195

    RECRUITING

    Coral Springs, Florida, 33071, United States

  • MediSearch Clinical Trials /ID# 263579

    RECRUITING

    Saint Joseph, Missouri, 64506, United States

  • Medical University of South Carolina /ID# 263655

    RECRUITING

    Charleston, South Carolina, 29425, United States

  • Modern Research Associates /ID# 263852

    RECRUITING

    Dallas, Texas, 75231, United States

  • NTT Medical Center Tokyo /ID# 265104

    RECRUITING

    Tokyo, 141-8625, Japan

  • NorCal Medical Research /ID# 278397

    RECRUITING

    Greenbrae, California, 94904, United States

  • Northwestern University Feinberg School of Medicine /ID# 264983

    RECRUITING

    Chicago, Illinois, 60611-2927, United States

  • Ogikubo Hospital /ID# 278350

    RECRUITING

    Suginami-Ku, Tokyo, 167-0035, Japan

  • One Of A Kind Clinical Research Center - Scottsdale /ID# 278675

    RECRUITING

    Scottsdale, Arizona, 85253, United States

  • Onyx Clinical Research - Flint - South Linden Road /ID# 267773

    COMPLETED

    Flint, Michigan, 48532, United States

  • Options Research Group /ID# 264564

    RECRUITING

    West Lafayette, Indiana, 47906, United States

  • Oregon Health and Science University /ID# 263736

    RECRUITING

    Portland, Oregon, 97239, United States

  • Orion Clinical Research /ID# 263658

    COMPLETED

    Austin, Texas, 78759, United States

  • Physician Research Collaboration, LLC /ID# 263583

    RECRUITING

    Lincoln, Nebraska, 68516, United States

  • Piedmont Plastic Surgery and Dermatology - Huntersville /ID# 266545

    RECRUITING

    Huntersville, North Carolina, 28078-7961, United States

  • Private Practice - Dr. Alma Cruz /ID# 263216

    RECRUITING

    Carolina, 00985, Puerto Rico

  • Private Practice - Dr. Orasan Remus /ID# 278765

    RECRUITING

    Cluj-Napoca, Cluj, 400006, Romania

  • Private Practice - Dr. Samuel Sanchez /ID# 263199

    RECRUITING

    Caguas, 00727, Puerto Rico

  • Private Practice - Dr. Tooraj Raoof /ID# 263849

    RECRUITING

    Encino, California, 91436, United States

  • Quality Research of South Florida /ID# 266496

    COMPLETED

    Miami Lakes, Florida, 33016, United States

  • Research Associates of South Florida /ID# 267291

    RECRUITING

    Miami, Florida, 33134, United States

  • Revival Research - Doral /ID# 263541

    COMPLETED

    Doral, Florida, 33122, United States

  • SCB Research Center /ID# 263217

    RECRUITING

    Bayamón, 00961, Puerto Rico

  • Seoul National University Hospital /ID# 263329

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Skin Cancer And Dermatology Institute (Scdi) - Reno /ID# 263771

    RECRUITING

    Reno, Nevada, 89509, United States

  • Skin Care Research - Hollywood /ID# 263739

    RECRUITING

    Hollywood, Florida, 33021-6748, United States

  • Skin Care Research - Tampa /ID# 263750

    RECRUITING

    Tampa, Florida, 33607-6438, United States

  • Skin Care Research Boca Raton /ID# 263733

    RECRUITING

    Boca Raton, Florida, 33486-2269, United States

  • Skin Specialists /ID# 263345

    RECRUITING

    Omaha, Nebraska, 68144, United States

  • Sms Clinical Research /ID# 278676

    RECRUITING

    Mesquite, Texas, 75149, United States

  • Solutions Through Advanced Research /ID# 263392

    COMPLETED

    Jacksonville, Florida, 32256, United States

  • Soon Chun Hyang University Hospital Bucheon /ID# 263331

    RECRUITING

    Bucheon-si, Gyeonggido, 14584, South Korea

  • Stanford University School of Medicine - Redwood City /ID# 263776

    RECRUITING

    Redwood City, California, 94063, United States

  • Stratica Medical /ID# 270466

    RECRUITING

    Edmonton, Alberta, T5K 2V4, Canada

  • Stride Clinical Research /ID# 267331

    RECRUITING

    Sugar Land, Texas, 77479, United States

  • Studies in Dermatology LLC /ID# 263335

    RECRUITING

    Cypress, Texas, 77429, United States

  • Sullivan Dermatology /ID# 263537

    RECRUITING

    Miami, Florida, 33162, United States

  • Tachikawa Dermatology Clinic /ID# 271912

    RECRUITING

    Tachikawa-shi, Tokyo, 190-0023, Japan

  • Takeoka Dermatology Clinic /ID# 264055

    RECRUITING

    Marugame, Kagawa-ken, 763-0074, Japan

  • Teikyo University Hospital /ID# 265126

    RECRUITING

    Tokyo, 173-8605, Japan

  • Texas Dermatology Research Center /ID# 264528

    COMPLETED

    Plano, Texas, 75025, United States

  • The Dermatology Institute of South Texas /ID# 267332

    COMPLETED

    McAllen, Texas, 78501, United States

  • The Woodlands Dermatology Associates /ID# 266547

    RECRUITING

    The Woodlands, Texas, 77380, United States

  • Treasure Valley Medical Research /ID# 263738

    RECRUITING

    Boise, Idaho, 83706, United States

  • TrueBlue Clinical Research - Brandon /ID# 265037

    RECRUITING

    Brandon, Florida, 33511, United States

  • Unidad Integral de Endocrinologia (UNIENDO) /ID# 266970

    RECRUITING

    Bogotá, Cundinamarca, 110221, Colombia

  • University Hospital Kyoto Prefectural University of Medicine /ID# 279353

    RECRUITING

    Kyoto, Kyoto, 602-8566, Japan

  • University of Pittsburgh Medical Center /ID# 264526

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

  • Velocity Clinical Research at The Dermatology Clinic - Baton Rouge /ID# 267169

    COMPLETED

    Baton Rouge, Louisiana, 70808-4691, United States

  • Vital Prospects Clinical Research Institute - Tulsa /ID# 263645

    COMPLETED

    Tulsa, Oklahoma, 74136, United States

  • Weill Cornell Medicine /ID# 265793

    RECRUITING

    New York, New York, 10065, United States

  • West Dermatology La Jolla /ID# 265014

    RECRUITING

    San Diego, California, 92121, United States

  • West Virginia Research Institute - Morgantown /ID# 264930

    RECRUITING

    Morgantown, West Virginia, 26505, United States

  • Yale University School of Medicine /ID# 263836

    RECRUITING

    New Haven, Connecticut, 06510, United States

  • Yamanashi Prefectural Central Hospital /ID# 278052

    RECRUITING

    Kofu, Yamanashi, 400-0027, Japan

  • York Dermatology Clinic & Research Centre /ID# 278847

    RECRUITING

    Richmond Hill, Ontario, L4C 9M7, Canada

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