Miscarriage mystery: 225 women to help scientists find answers
NCT ID NCT07293819
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
The FIRST-CARE study is a research project in Barcelona that will follow 225 women who have had a miscarriage in the first 14 weeks of pregnancy. Researchers will look at genetic, hormonal, immune, and other factors to better understand why miscarriages happen. The goal is to improve diagnosis and create personalized care plans for women and couples.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could lead to better diagnostic tools and personalized care plans for women who experience miscarriage, reducing emotional burden and improving reproductive health outcomes.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly provide new therapies. Results may take time to translate into clinical practice, and the sample size is modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 225 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2025
- Expected to finish
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Jun 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Women aged 18 years or older with a diagnosis of first-trimester missed miscarriage (gestational age \<14 weeks) will be enrolled. The study population will include two cohorts: women experiencing their first miscarriage and women with a history of recurrent pregnancy loss (defined as two or more previous first-trimester miscarriages). Participants will be recruited at the Hospital de la Santa Creu i Sant Pau (Barcelona, Spain) from outpatient and emergency gynecology services. Male partners will be invited to participate in selected assessments when applicable.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Female participants: Inclusion Criteria: * Women aged 18 years or older. * Diagnosis of missed miscarriage in the first trimester (\<14 weeks of gestation) confirmed by ultrasound. * Presence of an intrauterine pregnancy with fetal demise (clinical pregnancy loss). * Willing and able to provide written informed consent. * Ability to understand and complete study procedures. Exclusion Criteria: * Multiple pregnancy (twins or more). * Ectopic pregnancy. * Molar pregnancy (complete or partial hydatidiform mole). * Ongoing pregnancy with fetal cardiac activity. * Inability or unwillingness to comply with study procedures or follow-up. Male participants: no specific inclusion or exclusion criteria will apply to male partners, since the main inclusion criteria is a clinical pregnancy loss.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hospital de la Santa Creu i Sant Pau
NOT_YET_RECRUITINGBarcelona, Barcelona, 08025, Spain
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Hospital de la Santa Creu i Sant Pau
RECRUITINGBarcelona, Barcelona, 08025, Spain
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